Fransson Per
Department of Nursing, Umeå University, SE-901 87 Umeå, Sweden.
J Cancer Res Ther. 2010 Oct-Dec;6(4):516-20. doi: 10.4103/0973-1482.77076.
Limited information is available regarding the long-term effect of external beam radiotherapy (EBRT) on fatigue in individuals with prostate cancer (PC).
Men with PC treated with EBRT from January 1992 to June 2003 were enrolled in a prospective study. The QLQ-C30 questionnaire was used to evaluate pre-treatment fatigue and up to 5 years post-treatment.
407 men with 5-year assessments were analyzed. Fatigue increased between pre-treatment (mean: 15.5; CI: 13.6-17.4) and 5-years post-treatment (mean: 22.8; CI: 20.5-25.1; P<0.001). Pre-treatment fatigue was absent in 206/407 (59%) patients and 5-year post-treatment was reported by 264/407 (66%). Sixteen of 407 patients (4%) reported severe fatigue after 5 years. Physical-, emotional-, cognitive function, and dyspnea were the factors that correlated most to higher level of fatigue 5-year post-treatment.
Fatigue is a common symptom among patients with PC. A large percentage of patients reported pre-treatment fatigue. Fatigue increased over time, with the highest level seen at the end of EBRT. Severe fatigue was reported by 4% 5-year post-treatment. More work is needed in order to identify which patients are most susceptible to developing fatigue especially during radiotherapy.
关于外照射放疗（EBRT）对前列腺癌（PC）患者疲劳的长期影响，现有信息有限。
纳入1992年1月至2003年6月接受EBRT治疗的PC男性患者进行前瞻性研究。采用QLQ-C30问卷评估治疗前及治疗后长达5年的疲劳情况。
对407名有5年评估数据的男性进行了分析。疲劳程度在治疗前（均值：15.5；可信区间：13.6 - 17.4）至治疗后5年（均值：22.8；可信区间：20.5 - 25.1；P<0.001）有所增加。407名患者中有206名（59%）治疗前无疲劳，治疗后5年有264名（66%）报告有疲劳。407名患者中有16名（4%）在5年后报告有严重疲劳。身体、情绪、认知功能和呼吸困难是与治疗后5年疲劳水平较高最相关的因素。
疲劳是PC患者的常见症状。很大比例的患者报告治疗前有疲劳。疲劳随时间增加，在EBRT结束时达到最高水平。4%的患者在治疗后5年报告有严重疲劳。为确定哪些患者尤其在放疗期间最易出现疲劳，还需要开展更多工作。
