JMJD5 在拟南芥生物钟系统中与 TOC1 协同发挥作用。
JMJD5 Functions in concert with TOC1 in the arabidopsis circadian system.
机构信息
Department of Plant Biology, College of Biological Sciences, University of California, Davis, California, USA.
出版信息
Plant Signal Behav. 2011 Mar;6(3):445-8. doi: 10.4161/psb.6.3.14654. Epub 2011 Mar 1.
Abstract
The circadian clock modulates the expression of approximately one-third of Arabidopsis genes and as such plays a central role in the regulation of plant metabolism and responses to the environment. We have recently identified a novel component of the Arabidopsis circadian clock, JMJD5, based on its coexpression with TOC1, an evening-phased component of the molecular oscillator. We now examine the genetic interaction between TOC1 and JMJD5 in greater detail and demonstrate that toc1 is not epistatic to jmjd5, suggesting that these two proteins act in closely linked but parallel genetic pathways. The human homolog of JMJD5, KDM8, has been shown to have histone demethylation activity and is able to partially rescue the plant jmjd5 circadian phenotype. The potential role of JMJD5 as a histone demethylase within the circadian clock is discussed.
摘要
生物钟调节大约三分之一的拟南芥基因的表达，因此在植物代谢和对环境响应的调控中起着核心作用。我们最近基于其与 TOC1 的共表达，鉴定出了生物钟的一个新组件 JMJD5，而 TOC1 是分子振荡器中一个晚时相的组成部分。现在，我们更详细地研究了 TOC1 和 JMJD5 之间的遗传相互作用，并证明 toc1 不是 jmjd5 的上位基因，这表明这两种蛋白质在紧密相关但平行的遗传途径中发挥作用。JMJD5 的人同源物 KDM8 已被证明具有组蛋白去甲基化活性，并且能够部分挽救植物 jmjd5 的生物钟表型。讨论了 JMJD5 作为生物钟内组蛋白去甲基酶的潜在作用。
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