Department of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Molecules. 2011 Feb 28;16(3):2032-52. doi: 10.3390/molecules16032032.
With the appearance of the novel influenza A (H1N1) virus 2009 strain we have experienced a new influenza pandemic and many patients have died from severe complications associated with this pandemic despite receiving intensive care. This suggests that a definitive medical treatment for severe influenza-associated complications has not yet been established. Many studies have shown that superoxide anion produced by macrophages infiltrated into the virus-infected organs is implicated in the development of severe influenza-associated complications. Selected antioxidants, such as pyrrolidine dithiocabamate, N-acetyl-L-cysteine, glutathione, nordihydroguaiaretic acid, thujaplicin, resveratrol, (+)-vitisin A, ambroxol, ascorbic acid, 5,7,4-trihydroxy-8-methoxyflavone, catechins, quercetin 3-rhamnoside, iso- quercetin and oligonol, inhibit the proliferation of influenza virus and scavenge superoxide anion. The combination of antioxidants with antiviral drugs synergistically reduces the lethal effects of influenza virus infections. These results suggest that an agent with antiviral and antioxidant activities could be a drug of choice for the treatment of patients with severe influenza-associated complications. This review article updates knowledge of antioxidant therapy as a potential approach to severe influenza-associated complications.
随着新型甲型 H1N1 流感病毒的出现，我们经历了一场新的流感大流行，尽管接受了重症监护，但许多患者仍死于与大流行相关的严重并发症。这表明针对严重流感相关并发症的明确治疗方法尚未建立。许多研究表明，浸润到病毒感染器官的巨噬细胞产生的超氧阴离子参与了严重流感相关并发症的发展。一些抗氧化剂，如吡咯烷二硫代氨基甲酸盐、N-乙酰-L-半胱氨酸、谷胱甘肽、去甲二氢愈创木酸、土木香内酯、白藜芦醇、(+)-葡萄素 A、氨溴索、抗坏血酸、5,7,4-三羟基-8-甲氧基黄酮、儿茶素、槲皮素 3-鼠李糖苷、异槲皮苷和低聚原花青素，能抑制流感病毒的增殖并清除超氧阴离子。抗氧化剂与抗病毒药物联合使用可协同降低流感病毒感染的致死作用。这些结果表明，具有抗病毒和抗氧化活性的药物可能是治疗严重流感相关并发症患者的首选药物。本文综述了抗氧化治疗作为严重流感相关并发症潜在治疗方法的最新知识。
