血清一氧化氮代谢产物作为内脏脂肪堆积的生物标志物：硝酸盐/亚硝酸盐测量的临床意义。

Serum nitric oxide metabolite as a biomarker of visceral fat accumulation: clinical significance of measurement for nitrate/nitrite.

机构信息

Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan.

出版信息

Med Sci Monit. 2011 Feb 25;17(3):CR123-31. doi: 10.12659/msm.881445.

BACKGROUND

A visceral fat area of more than 100 cm2 as measured by computed tomography (CT) at the umbilical level has been included as a criterion for obesity in all the proposed criteria for metabolic syndrome. However, CT cannot be used frequently because of radiation exposure. We evaluated the usefulness of measurement of the serum levels of nitric oxide (NO), instead of CT and the waist circumference, as a marker of abdominal visceral fat accumulation.

MATERIAL/METHODS: The study was carried out in 80 subjects. The serum levels of NO metabolites (nitrate/nitrite) were measured using the Griess reagent.

RESULTS

Simple and multiple regression analysis revealed that the serum levels of NO metabolites showed the greatest degree of correlation with the visceral fat area (r = 0.743, p<0.0001), and corresponded to a visceral fat area of 100 cm2, as determined using the ROC curve, was 21.0 µmol/ml (sensitivity 88%, specificity 82%); this method was more sensitive than the waist circumference for evaluation of the visceral fat accumulation.

CONCLUSIONS

Measurement of the serum levels of NO metabolites may be a simple, safe, convenient and reliable method for the evaluation of visceral fat accumulation in clinical diagnostic screening.

背景

在所有提出的代谢综合征标准中，都将脐水平 CT 测量的内脏脂肪面积超过 100 cm2 纳入肥胖标准。然而，由于辐射暴露，CT 不能频繁使用。我们评估了测量血清一氧化氮（NO）水平作为腹部内脏脂肪堆积的标志物的有用性，而不是 CT 和腰围。

材料/方法：该研究在 80 名受试者中进行。使用格里塞试剂测量血清 NO 代谢物（硝酸盐/亚硝酸盐）的水平。

结果

简单和多元回归分析显示，血清 NO 代谢物水平与内脏脂肪面积相关性最强（r = 0.743，p<0.0001），与 ROC 曲线确定的 100 cm2 内脏脂肪面积相对应的血清 NO 代谢物水平为 21.0 µmol/ml（敏感性 88%，特异性 82%）；该方法比腰围更敏感，更适合评估内脏脂肪堆积。