Fujie Shumpei, Hasegawa Natsuki, Kurihara Toshiyuki, Sanada Kiyoshi, Hamaoka Takafumi, Iemitsu Motoyuki
a Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
b Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan.
Appl Physiol Nutr Metab. 2017 Jan;42(1):8-14. doi: 10.1139/apnm-2016-0310. Epub 2016 Sep 13.
Serum levels of adropin, which enhances endothelial cell release of nitric oxide (NO), are lower in obese patients. Although habitual aerobic exercise reduces arterial stiffness and adiposity, the relationship between these effects and circulating levels of adropin remains unclear. The purpose of this study was to determine if serum adropin level is associated with the effects of aerobic exercise training on arterial stiffness and adiposity in obese adults. In Experiment 1, we examined whether serum adropin levels are associated with cardiorespiratory fitness, carotid β-stiffness, plasma nitrite/nitrate (NOx) level, and abdominal visceral fat in 27 normal, 20 overweight, and 25 obese adults (age, 41-79 years). In Experiment 2, we examined the effects of an 8-week aerobic exercise training program on the relationship between serum adropin level and arterial stiffness or adiposity in 13 obese adults (age, 54-76 years). Serum adropin levels in normal, overweight, and obese adults negatively correlated with carotid β-stiffness and abdominal visceral fat, and positively correlated with plasma NOx level and cardiorespiratory fitness. After the 8-week exercise program, serum adropin levels in obese adults were elevated, and correlated with training-induced changes in carotid β-stiffness (r = -0.573, P < 0.05), plasma NOx level (r = 0.671, P < 0.05), and abdominal visceral fat (r = -0.585, P < 0.05). These findings suggest that the exercise training-induced increase in serum adropin may be related to the training effects of arterial stiffness and adiposity in obese adults.
增强内皮细胞一氧化氮（NO）释放的内脂素血清水平在肥胖患者中较低。尽管习惯性有氧运动可降低动脉僵硬度和肥胖程度，但这些作用与循环内脂素水平之间的关系仍不清楚。本研究的目的是确定血清内脂素水平是否与有氧运动训练对肥胖成年人动脉僵硬度和肥胖程度的影响相关。在实验1中，我们检测了27名正常、20名超重和25名肥胖成年人（年龄41 - 79岁）的血清内脂素水平是否与心肺适能、颈动脉β僵硬度、血浆亚硝酸盐/硝酸盐（NOx）水平和腹部内脏脂肪相关。在实验2中，我们检测了一项为期8周的有氧运动训练计划对13名肥胖成年人（年龄54 - 76岁）血清内脂素水平与动脉僵硬度或肥胖程度之间关系的影响。正常、超重和肥胖成年人的血清内脂素水平与颈动脉β僵硬度和腹部内脏脂肪呈负相关，与血浆NOx水平和心肺适能呈正相关。经过8周的运动计划后，肥胖成年人的血清内脂素水平升高，并与训练引起的颈动脉β僵硬度变化（r = -0.573，P < 0.05）、血浆NOx水平变化（r = 0.671，P < 0.05）和腹部内脏脂肪变化（r = -0.585，P < 0.05）相关。这些发现表明，运动训练引起的血清内脂素升高可能与肥胖成年人动脉僵硬度和肥胖程度的训练效果有关。
