CD4 T 细胞免疫对抗流感的特征。
Hallmarks of CD4 T cell immunity against influenza.
机构信息
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
出版信息
J Intern Med. 2011 May;269(5):507-18. doi: 10.1111/j.1365-2796.2011.02367.x. Epub 2011 Mar 25.
Abstract
The mechanisms responsible for heterosubtypic immunity to influenza virus are not well understood but might hold the key for new vaccine strategies capable of providing lasting protection against both seasonal and pandemic strains. Memory CD4 T cells are capable of providing substantial protection against influenza both through direct effector mechanisms and indirectly through regulatory and helper functions. Here, we discuss the broad impact of memory CD4 T cells on heterosubtypic immunity against influenza and the prospects of translating findings from animal models into improved human influenza vaccines.
摘要
负责流感病毒异源免疫的机制尚不清楚，但可能是新疫苗策略的关键，这种策略能够提供针对季节性和大流行毒株的持久保护。记忆 CD4 T 细胞能够通过直接效应机制和间接的调节和辅助功能，为流感提供实质性的保护。在这里，我们讨论了记忆 CD4 T 细胞对流感异源免疫的广泛影响，以及将动物模型中的发现转化为改进的人类流感疫苗的前景。
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