Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, J7.104C, Dallas, TX 75390-8511, USA.
Mol Cell. 2011 Mar 4;41(5):497-9. doi: 10.1016/j.molcel.2011.02.019.
In this issue, Katoh et al. (2011) show that the biosynthetic enzyme MATIIα binds at the locus in mammalian cells and exhibits transcriptional corepressor activity through local production of -adenosylmethionine, which stimulates histone methyltransferases to promote a transcriptionally repressive chromatin environment.
在本期中，Katoh 等人（2011）表明生物合成酶 MATIIα 在哺乳动物细胞中结合在 基因座上，并通过局部产生 - 腺苷甲硫氨酸表现出转录核心抑制活性，这刺激组蛋白甲基转移酶促进转录抑制性染色质环境。
