小分子，大作用：染色质定位的代谢物生物合成在基因调控中的作用。
Small molecules, big effects: a role for chromatin-localized metabolite biosynthesis in gene regulation.
机构信息
Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, J7.104C, Dallas, TX 75390-8511, USA.
出版信息
Mol Cell. 2011 Mar 4;41(5):497-9. doi: 10.1016/j.molcel.2011.02.019.
Abstract
In this issue, Katoh et al. (2011) show that the biosynthetic enzyme MATIIα binds at the locus in mammalian cells and exhibits transcriptional corepressor activity through local production of -adenosylmethionine, which stimulates histone methyltransferases to promote a transcriptionally repressive chromatin environment.
摘要
在本期中，Katoh 等人（2011）表明生物合成酶 MATIIα 在哺乳动物细胞中结合在 基因座上，并通过局部产生 - 腺苷甲硫氨酸表现出转录核心抑制活性，这刺激组蛋白甲基转移酶促进转录抑制性染色质环境。
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