琥珀酸在 DNA 修复中的作用。
Fumarate in DNA repair.
机构信息
Departments of Biochemistry &Molecular Biology and Oncology, Robson DNA Science Centre, Southern Alberta Cancer Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.
出版信息
Nat Cell Biol. 2015 Sep;17(9):1096-7. doi: 10.1038/ncb3232.
DOI:10.1038/ncb3232
PMID:26316455
Abstract
A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.
摘要
一项新的研究表明，通常与线粒体中 ATP 产生相关的代谢酶延胡索酸酶被招募到 DNA 损伤部位，在那里产生延胡索酸以抑制组蛋白去甲基化并促进 DNA 双链断裂的修复。
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