Department of Environmental Health Sciences, School of Public Health, University at Albany, Rensselaer, New York, USA.
Environ Health Perspect. 2011 Mar;119(3):319-25. doi: 10.1289/ehp.1002830.
Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed.
The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB groups with common actions or structure, 35 individual PCB congeners, and nine chlorinated pesticides.
Linear regression analysis was used to determine the relationships between blood pressure and serum levels of the various contaminants after adjustment for age, body mass index, sex, race, smoking, and exercise in 394 Anniston residents who were not taking antihypertensive medication.
Other than age, total serum PCB concentration was the strongest determinant of blood pressure of the covariates studied. We found the strongest associations for those PCB congeners that had multiple ortho chlorines. We found the associations over the full range of blood pressure as well as in those subjects whose blood pressure was in the normal range. The chlorinated pesticides showed no consistent relationship to blood pressure.
In this cross-sectional study, serum concentrations of PCBs, especially those congeners with multiple ortho chlorines, were strongly associated with both systolic and diastolic blood pressure.
阿拉巴马州安尼斯顿的居民居住在孟山都工厂附近，该工厂从 1929 年至 1971 年生产多氯联苯（PCBs），并且暴露程度相对较高。
本研究的目的是确定血压与总血清 PCBs 水平、具有共同作用或结构的几种 PCB 组、35 种单个 PCB 同系物和 9 种氯化农药之间是否存在任何关系。
在 394 名未服用抗高血压药物的安尼斯顿居民中，通过线性回归分析确定了血压与各种污染物血清水平之间的关系，这些居民经过年龄、体重指数、性别、种族、吸烟和运动调整。
除年龄外，总血清 PCB 浓度是研究中协变量中血压的最强决定因素。我们发现具有多个邻位氯的那些 PCB 同系物具有最强的相关性。我们在血压的全范围内以及血压正常的受试者中都发现了这种相关性。氯化农药与血压没有一致的关系。
在这项横断面研究中，血清 PCBs 浓度，特别是具有多个邻位氯的那些同系物，与收缩压和舒张压均有强烈关联。
