消除癌症。
Ironing out cancer.
机构信息
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA.
出版信息
Cancer Res. 2011 Mar 1;71(5):1511-4. doi: 10.1158/0008-5472.CAN-10-3614.
Abstract
New insights into the roles of proteins that regulate cellular iron in cancer growth, angiogenesis, and metastasis have recently emerged. Discoveries of the roles of ferroportin, hepcidin, lipocalin 2, and members of the six transmembrane epithelial antigen of the prostate (STEAP) and iron regulatory protein (IRP) families in cancer have provided specificity and molecular definition to the role of iron homeostasis in cancer growth and metastasis. A number of studies directly support a role of these proteins in modifying bioavailable iron, whereas other studies suggest that at least some of their effects are independent of their role in iron biology.
摘要
最近，人们对调节细胞铁的蛋白质在癌症生长、血管生成和转移中的作用有了新的认识。铁蛋白、hepcidin、脂联素 2 以及六跨膜上皮抗原前列腺（STEAP）和铁调节蛋白（IRP）家族成员在癌症中的作用的发现，为铁平衡在癌症生长和转移中的作用提供了特异性和分子定义。许多研究直接支持这些蛋白质在调节生物可利用铁中的作用，而其他研究表明，至少它们的一些作用与其在铁生物学中的作用无关。
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