Emmanuel Benjamin, Kawira Esther, Ogwang Martin D, Wabinga Henry, Magatti Josiah, Nkrumah Francis, Neequaye Janet, Bhatia Kishor, Brubaker Glen, Biggar Robert J, Mbulaiteye Sam M
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20852, USA.
Am J Trop Med Hyg. 2011 Mar;84(3):397-401. doi: 10.4269/ajtmh.2011.10-0450.
African Burkitt lymphoma is an aggressive B-cell, non-Hodgkin lymphoma linked to Plasmodium falciparum malaria. Malaria biomarkers related to onset of African Burkitt lymphoma are unknown. We correlated age-specific patterns of 2,602 cases of African Burkitt lymphoma (60% male, mean ± SD age = 7.1 ± 2.9 years) from Uganda, Ghana, and Tanzania with malaria biomarkers published from these countries. Age-specific patterns of this disease and mean multiplicity of P. falciparum malaria parasites, defined as the average number of distinct genotypes per positive blood sample based on the merozoite surface protein-2 assessed by polymerase chain reaction, were correlated and both peaked between 5 and 9 years. This pattern, which was strong and consistent across regions, contrasted parasite prevalence, which peaked at 2 years and decreased slightly, and geometric mean parasite density, which peaked between 2 and 3 years and decreased sharply. Our findings suggest that concurrent infection with multiple malaria genotypes may be related to onset of African Burkitt lymphoma.
非洲伯基特淋巴瘤是一种侵袭性B细胞非霍奇金淋巴瘤，与恶性疟原虫疟疾有关。与非洲伯基特淋巴瘤发病相关的疟疾生物标志物尚不清楚。我们将来自乌干达、加纳和坦桑尼亚的2602例非洲伯基特淋巴瘤病例（60%为男性，平均年龄±标准差=7.1±2.9岁）的年龄特异性模式与这些国家公布的疟疾生物标志物进行了关联分析。该疾病的年龄特异性模式与恶性疟原虫疟疾寄生虫的平均克隆多样性（定义为基于通过聚合酶链反应评估的裂殖子表面蛋白-2，每个阳性血样中不同基因型的平均数）进行了关联分析，两者均在5至9岁达到峰值。这种模式在各地区都很强且一致，与寄生虫流行率形成对比，后者在2岁时达到峰值并略有下降，以及几何平均寄生虫密度，其在2至3岁达到峰值并急剧下降。我们的研究结果表明，同时感染多种疟疾基因型可能与非洲伯基特淋巴瘤的发病有关。
