马拉维恶性疟原虫疟疾流行率、遗传多样性与地方性伯基特淋巴瘤之间的关系
Relationship between Plasmodium falciparum malaria prevalence, genetic diversity and endemic Burkitt lymphoma in Malawi.
作者信息
Johnston W Thomas, Mutalima Nora, Sun David, Emmanuel Benjamin, Bhatia Kishor, Aka Peter, Wu Xiaolin, Borgstein E, Liomba G N, Kamiza Steve, Mkandawire Nyengo, Batumba Mkume, Carpenter Lucy M, Jaffe Harold, Molyneux Elizabeth M, Goedert James J, Soppet Daniel, Newton Robert, Mbulaiteye Sam M
机构信息
University of York, York, United Kingdom.
Frederick National Laboratory for Cancer Research, Frederick, Maryland.
出版信息
Sci Rep. 2014 Jan 17;4:3741. doi: 10.1038/srep03741.
Endemic Burkitt lymphoma (eBL) has been linked to Plasmodium falciparum (Pf) malaria infection, but the contribution of infection with multiple Pf genotypes is uncertain. We studied 303 eBL (cases) and 274 non eBL-related cancers (controls) in Malawi using a sensitive and specific molecular-barcode array of 24 independently segregating Pf single nucleotide polymorphisms. Cases had a higher Pf malaria prevalence than controls (64.7% versus 45.3%; odds ratio [OR] 2.1, 95% confidence interval (CI): 1.5 to 3.1). Cases and controls were similar in terms of Pf density (4.9 versus 4.5 log copies, p = 0.28) and having ≥3 non-clonal calls (OR 2.7, 95% CI: 0.7-9.9, P = 0.14). However, cases were more likely to have a higher Pf genetic diversity score (153.9 versus 133.1, p = 0.036), which measures a combination of clonal and non-clonal calls, than controls. Further work is needed to evaluate the possible role of Pf genetic diversity in the pathogenesis of endemic BL.
地方性伯基特淋巴瘤（eBL）与恶性疟原虫（Pf）疟疾感染有关，但感染多种Pf基因型的作用尚不确定。我们在马拉维使用一种对24个独立分离的Pf单核苷酸多态性敏感且特异的分子条形码阵列，研究了303例eBL（病例）和274例非eBL相关癌症（对照）。病例的Pf疟疾患病率高于对照（64.7%对45.3%；比值比[OR]2.1，95%置信区间[CI]：1.5至3.1）。病例和对照在Pf密度方面相似（4.9对4.5 log拷贝，p = 0.28），且具有≥3个非克隆呼叫（OR 2.7，95%CI：0.7 - 9.9，P = 0.14）。然而，病例比对照更有可能具有更高的Pf遗传多样性评分（153.9对133.1，p = 0.036），该评分衡量克隆和非克隆呼叫的组合。需要进一步开展工作来评估Pf遗传多样性在地方性BL发病机制中的可能作用。
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