Hatta Mochammad, Sultan Andi R, Pastoor Rob, Smits Henk L
Department of Medical Microbiology, Molecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin University, Makassar, South-Sulawesi, Indonesia.
Am J Trop Med Hyg. 2011 Mar;84(3):429-34. doi: 10.4269/ajtmh.2011.10-0605.
Phase variation is a property unique of some Salmonella enterica serovar Typhi strains from Indonesia. Salmonella Typhi isolates from Indonesia have been described that in addition to the phase 1 Hd flagellin gene contain a second flagellin gene named z66. S. Typhi isolates from Indonesia with a mutant Hd gene named Hj have also been described. Here, we have identified another flagellin gene of S. Typhi, named Ind, showing a closest homology with the flagellin gene of Serratia marcescens. The Ind gene was detected in 21.8% of the S. Typhi isolates from the East Indonesian archipelago, all of which contained the Hd gene. The Hj gene was not detected. The z66 gene was present in 15.4% of the isolates. The presence of these "foreign" flagellin genes could be associated with an increased risk for developing severe disease.
相位变异是印度尼西亚一些伤寒沙门氏菌血清型菌株特有的特性。已经描述了来自印度尼西亚的伤寒沙门氏菌分离株，除了1相Hd鞭毛蛋白基因外，还含有另一个名为z66的鞭毛蛋白基因。还描述了来自印度尼西亚的具有名为Hj的突变Hd基因的伤寒沙门氏菌分离株。在这里，我们鉴定了伤寒沙门氏菌的另一个鞭毛蛋白基因，名为Ind，与粘质沙雷氏菌的鞭毛蛋白基因具有最密切的同源性。在来自印度尼西亚东部群岛的21.8%的伤寒沙门氏菌分离株中检测到Ind基因，所有这些分离株都含有Hd基因。未检测到Hj基因。15.4%的分离株中存在z66基因。这些“外来”鞭毛蛋白基因的存在可能与发生严重疾病的风险增加有关。
