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[阿米巴病免疫诊断试验的评估:诊断还是偏差?文献综述]

[Evaluation of immunologic diagnostic tests in amebiasis: diagnosis or bias? A critical review of the literature].

作者信息

Garduño-Espinosa J, Martínez-García M C, Gómez-Delgado A, Mejía Arangure J M, Ortega Alvarez M, Rendón-Macías E, Robles-Pérez E, Muñoz-Hernández O

机构信息

Depto. de Epidemiología Clínica, Hospital de Pediatría, C.M.N.-I.M.S.S., México, D.F.

出版信息

Arch Invest Med (Mex). 1990;21 Suppl 1:277-84.

PMID:2136498
Abstract

OBJECTIVE

  1. To describe the frequency of adherence to methodologic criteria proposed for assessment of diagnostic tests. 2. To identify potential bias. 3. To construct Receiver Operating Characteristic (ROC) curves based on data published on the assessed papers.

DESIGN

Descriptive cross-sectional survey.

STUDY MATERIAL

All papers listed under diagnosis and immunological headings of amebiasis in the Index Medicus from 1970 to 1988.

STUDY UNITS

80 papers.

MEASUREMENT

a: Adherence to methodologic criteria proposed for assessment of diagnostic test. b: presence of potential bias.

MAIN RESULTS

The adherence to methodologic criteria varied 1 to 55% of the papers. The comparison with a "gold standard" occurred in 40% the independent "blind" assessment occurred in 6% the setting for the study was described 1%. The study of an appropriate spectrum of disease was done in 11%. We were able to construct ROC curves with data from 37 papers and differences were observed among studies evaluating the same test. A high proportion of papers had potential bias.

CONCLUSIONS

The adherence to methodologic standards is poor in the papers analyzed in this series. Consequently the frequency of potential bias was high.

摘要

目的

  1. 描述遵循用于评估诊断试验的方法学标准的频率。2. 识别潜在偏倚。3. 根据评估论文中发表的数据构建受试者操作特征(ROC)曲线。

设计

描述性横断面调查。

研究材料

1970年至1988年《医学索引》中阿米巴病诊断和免疫学标题下列出的所有论文。

研究单位

80篇论文。

测量指标

a:遵循用于评估诊断试验的方法学标准的情况。b:潜在偏倚的存在情况。

主要结果

遵循方法学标准的论文比例在1%至55%之间。与“金标准”进行比较的论文占40%,独立“盲法”评估的论文占6%,描述研究背景的论文占1%。对适当疾病谱进行研究的论文占11%。我们能够根据37篇论文的数据构建ROC曲线,并且在评估相同试验的研究之间观察到了差异。很大一部分论文存在潜在偏倚。

结论

本系列分析的论文对方法学标准的遵循情况较差。因此,潜在偏倚的频率较高。

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Arch Invest Med (Mex). 1990;21 Suppl 1:277-84.
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