Laboratório de Fisiopatologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Av Universitária, 1105 Bairro Universitário, Criciúma, SC 88806-000, Brazil.
Neurochem Res. 2011 Jun;36(6):962-6. doi: 10.1007/s11064-011-0432-3. Epub 2011 Mar 2.
The highly active antiretroviral therapy completely changed the clinical evolution of HIV infection, reducing the morbidity and mortality among human immunodeficiency virus (HIV)-1 infected patients. Therefore, in the present study we evaluated the effect of chronic efavirenz (EFV) and nevirapine (NVP) administration on mitochondrial respiratory chain complexes activities (I, II, II-III, IV) in different brain regions of mice. Mice were orally administered via gavage with EFV 10 mg/kg, NVP 3.3 mg/kg or vehicle (controls) once a day for 36 days. We observed that the complex IV activity was inhibited by both EFV and NVP in cerebral cortex, striatum and hippocampus of mice, but not in cerebellum, as compared to control group. In contrast, chronic EFV and NVP administration did not alter complexes I, II and II-III. We speculated that brain energy metabolism dysfunction could be involved in the CNS-related adverse effects.
高效抗逆转录病毒疗法（Highly active antiretroviral therapy，HAART）完全改变了人类免疫缺陷病毒（HIV）感染的临床进程，降低了 HIV-1 感染患者的发病率和死亡率。因此，在本研究中，我们评估了慢性依非韦伦（Efavirenz，EFV）和奈韦拉平（Nevirapine，NVP）给药对不同脑区中小鼠线粒体呼吸链复合物活性（复合物 I、II、II-III、IV）的影响。通过灌胃，每天一次给予小鼠 EFV 10mg/kg、NVP 3.3mg/kg 或载体（对照组），共 36 天。结果显示，与对照组相比，EFV 和 NVP 均可抑制大脑皮质、纹状体和海马中的复合物 IV 活性，但对小脑没有影响。相反，慢性 EFV 和 NVP 给药并不改变复合物 I、II 和 II-III。我们推测，脑能量代谢功能障碍可能与中枢神经系统相关的不良反应有关。
