犬肝脏再生：形态学和化学变化
Liver regeneration in dogs: morphologic and chemical changes.
作者信息
Francavilla A, Porter K A, Benichou J, Jones A F, Starzl T E
出版信息
J Surg Res. 1978 Nov;25(5):409-19. doi: 10.1016/s0022-4804(78)80005-5.
Abstract
Forty-four percent and 72% hepatectomy were carried out in dogs and the animals were sacrificed for biochemical and pathologic studies from 0.5 to 6 days later. Compensatory hypertrophy and hyperplasia (“regeneration”) were evident within 1 day, reached a maximum in 3 days, and were almost complete by 6 days. Coincident with the histologic events of regeneration were decreases in responsiveness of receptor adenyl cyclase to glucagon stimulation, increases of cyclic AMP, inconsistent changes in plasma insulin, and increases in plasma glucagon. These studies have standardized hepatic resection in dogs and they have focused attention upon some possible mechanisms that will require further study.
摘要
在狗身上进行了44%和72%的肝切除术，术后0.5至6天处死动物进行生化和病理学研究。1天内即可明显观察到代偿性肥大和增生（“再生”），3天达到最大程度，6天时几乎完成。与再生的组织学变化同时出现的是，受体腺苷酸环化酶对胰高血糖素刺激的反应性降低、环磷酸腺苷增加、血浆胰岛素变化不一致以及血浆胰高血糖素增加。这些研究规范了狗的肝切除术，并使人们关注到一些可能需要进一步研究的机制。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
USE OF LIVER ADENYL CYCLASE FOR ASSAY OF GLUCAGON IN HUMAN GASTRO-INTESTINAL TRACT AND PANCREAS.利用肝脏腺苷酸环化酶测定人胃肠道和胰腺中的胰高血糖素
Endocrinology. 1964 Jul;75:127-34. doi: 10.1210/endo-75-1-127.
3
Regeneration of the liver.
Gastroenterology. 1959 Nov;37:657-678.
4
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
Biochem J. 1956 Feb;62(2):315-23. doi: 10.1042/bj0620315.
5
A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells.正常大鼠肝实质细胞超微结构的定量体视学描述
J Cell Biol. 1968 Apr;37(1):27-46. doi: 10.1083/jcb.37.1.27.
6
Incorporation of pyrimidine deoxyribonucleosides into liver lipids and other components.
Biochim Biophys Acta. 1971 Feb 11;228(3):610-26. doi: 10.1016/0005-2787(71)90725-8.
7
Coated charcoal immunoassay of insulin.胰岛素的包被炭免疫测定法。
J Clin Endocrinol Metab. 1965 Oct;25(10):1375-84. doi: 10.1210/jcem-25-10-1375.
8
Evaluation of a humoral factor in liver regeneration utilizing liver transplants.利用肝移植评估肝脏再生中的一种体液因子。
Cancer Res. 1971 Mar;31(3):322-31.
9
Growth control of differentiated fetal rat hepatocytes in primary monolayer culture. VII. Hormonal control of DNA synthesis and its possible significance to the problem of liver regeneration.原代单层培养中分化的胎鼠肝细胞的生长控制。VII. DNA合成的激素控制及其对肝再生问题的可能意义。
J Cell Biol. 1974 Sep;62(3):792-801. doi: 10.1083/jcb.62.3.792.
10
A highly sensitive adenylate cyclase assay.一种高灵敏度的腺苷酸环化酶检测方法。
Anal Biochem. 1974 Apr;58(2):541-8. doi: 10.1016/0003-2697(74)90222-x.
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