Buzoianu Ioana Cristina, Arghir Oana Cristina, Circo E
Spitalul Clinic Judeţean de Urgenţă Constanţa.
Pneumologia. 2010 Oct-Dec;59(4):211-4.
The chronic autoimmune thyroiditis are heterogeneous entities by the functional, lesional and evolutive point of view. Ethiopathogenic factors involved in chronic autoimmune thyroiditis are genetical factors, combines with environmental factors, hormonal factors, infectious factors etc. The exact role of smoking on the autoimmune mechanism is unclear, but smoking is known to have an antithyroid effect.
Our study tries to estimate the influence of smoking on serum levels of antithyroid peroxidase antibodies and antithyroglobulin antibodies, in a group of patients with various clinical forms of chronic autoimmune thyroiditis.
We studied a group consists of 310 patients with chronic autoimmune thyroiditis, hospitalised in the Endocrinology Department of Constanta County Hospital, between January 2006 - December 2009. We detected serum values of antithyroidperoxidase antibodies and antithyroglobulin antibodies of our patients. We also followed the age, sex and presence of smoking in our study group. For statistical processing of the data we use Student's t-test.
In our study group 24.28% of patients were smokers. Serum levels of antithyroid peroxidase antibodies were significantly increased (p < 0.001) in the smokers patients, compared with the nonsmokers patients. Serum levels of antithyroglobulin antibodies were significantly increased (p < 0.01) in smokers patients, compared with those who were nonsmokers.
Smoking increased the serum levels of antithyroid antibodies in patients with chronic autoimmune thyroiditis.
从功能、病变和演变的角度来看，慢性自身免疫性甲状腺炎是异质性疾病。参与慢性自身免疫性甲状腺炎的发病因素包括遗传因素，它与环境因素、激素因素、感染因素等相结合。吸烟对自身免疫机制的确切作用尚不清楚，但已知吸烟具有抗甲状腺作用。
我们的研究试图评估吸烟对一组患有各种临床形式慢性自身免疫性甲状腺炎患者血清抗甲状腺过氧化物酶抗体和抗甲状腺球蛋白抗体水平的影响。
我们研究了一组由310例慢性自身免疫性甲状腺炎患者组成的群体，这些患者于2006年1月至2009年12月期间在康斯坦察县医院内分泌科住院。我们检测了患者血清中抗甲状腺过氧化物酶抗体和抗甲状腺球蛋白抗体的值。我们还记录了研究组患者的年龄、性别和吸烟情况。对于数据的统计处理，我们使用学生t检验。
在我们的研究组中，24.28%的患者吸烟。与不吸烟患者相比，吸烟患者血清抗甲状腺过氧化物酶抗体水平显著升高（p < 0.001）。与不吸烟患者相比，吸烟患者血清抗甲状腺球蛋白抗体水平显著升高（p < 0.01）。
吸烟会增加慢性自身免疫性甲状腺炎患者血清抗甲状腺抗体水平。
