Guo Dong-Xiao, Du Yu, Wang Yan-Yan, Sun Ling-Mei, Qu Jian-Bo, Wang Xiao-Ning, Lou Hong-Xiang
Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.
Nat Prod Commun. 2009 Oct;4(10):1319-22.
A new trinortriterpenoid, diospyrolide acetate (1) and a new diphenylmethane derivative, pulcherrimumin (12), together with ten known pentacyclic triterpenoids (2-11) and four aromatic compounds (13-16), were isolated from the liverwort Ptilidium pulcherrimum. Their structures were established on the basis of extensive analysis of NMR data and by chemical methods. The cytotoxicity of compounds 1-16 was evaluated against the PC3, MDA-MB-231, and Hela cells lines. Ursane triterpenoids 8-10 exhibited moderate cytotoxicity against PC3 cells with IC50 values ranging from 10.1 to 39.7 microM.
从地钱美丽耳叶苔中分离得到一个新的三降三萜类化合物——醋酸地钱螺内酯（1）、一个新的二苯基甲烷衍生物——美丽耳叶苔素（12），以及十个已知的五环三萜类化合物（2 - 11）和四种芳香族化合物（13 - 16）。通过对核磁共振数据的广泛分析和化学方法确定了它们的结构。评估了化合物1 - 16对PC3、MDA - MB - 231和Hela细胞系的细胞毒性。乌苏烷型三萜类化合物8 - 10对PC3细胞表现出中等细胞毒性，IC50值在10.1至39.7微摩尔之间。
