Institut de Génétique Moléculaire de Montpellier, CNRS UMR 5535, 34293 Montpellier, France.
Future Microbiol. 2011 Feb;6(2):179-92. doi: 10.2217/fmb.10.162.
Adenoviruses have a bipolar nature: they are ubiquitous pathogens that occasionally cause life-threatening diseases or they can be engineered into powerful gene transfer vectors. The goal of this article is to summarize the most recent advances in adenovirus receptor engagement, internalization, endosomal maturation, endosomal escape and trafficking to the nuclear pore. A better understanding of this initial part of the adenovirus lifecycle may identify new mechanistic-based treatments for adenovirus-induced diseases and help in the engineering of more efficient vectors.
它们是普遍存在的病原体，偶尔会导致危及生命的疾病，或者可以被设计成强大的基因转移载体。本文的目的是总结腺病毒受体结合、内化、内体成熟、内体逃逸和向核孔运输的最新进展。更好地了解腺病毒生命周期的这一初始部分可能会为腺病毒诱导的疾病确定新的基于机制的治疗方法，并有助于工程更有效的载体。
