Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Viruses. 2011 Aug;3(8):1417-31. doi: 10.3390/v3081417. Epub 2011 Aug 12.
Following receptor-mediated uptake into endocytic vesicles and escape from the endosome, adenovirus is transported by cytoplasmic dynein along microtubules to the perinuclear region of the cell. How motor proteins are recruited to viruses for their own use has begun to be investigated only recently. We review here the evidence for a role for dynein and other motor proteins in adenovirus infectivity. We also discuss the implications of recent studies on the mechanism of dynein recruitment to adenovirus for understanding the relationship between pathogenic and physiological cargo recruitment and for the evolutionary origins of dynein-mediated adenovirus transport.
腺病毒通过受体介导的内吞作用进入内体小泡，并从内体小泡逃逸后，由细胞质动力蛋白沿微管运输到细胞的核周区域。最近才开始研究马达蛋白如何被招募来用于病毒本身。我们在此综述了动力蛋白和其他马达蛋白在腺病毒感染性中的作用的证据。我们还讨论了最近关于动力蛋白招募到腺病毒的机制的研究对理解致病性和生理性货物招募之间的关系以及对动力蛋白介导的腺病毒运输的进化起源的影响。
