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用于超精确激光组织手术的接触聚焦多模态微探针。

Contact focusing multimodal microprobes for ultraprecise laser tissue surgery.

作者信息

Darafsheh Arash, Fardad Amir, Fried Nathaniel M, Antoszyk Andrew N, Ying Howard S, Astratov Vasily N

机构信息

Department of Physics and Optical Science, Center for Optoelectronics and Optical Communications, University of North Carolina at Charlotte, NC 28223, USA.

出版信息

Opt Express. 2011 Feb 14;19(4):3440-8. doi: 10.1364/OE.19.003440.

DOI:10.1364/OE.19.003440
PMID:21369166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3368307/
Abstract

Focusing of multimodal beams by chains of dielectric microspheres assembled directly inside the cores of hollow waveguides is studied by using numerical ray tracing. The device designs are optimized for laser surgery in contact mode with strongly absorbing tissue. By analyzing a broad range of parameters it is demonstrated that chains formed by three or five spheres with a refractive index of 1.65-1.75 provide a two-fold improvement in spatial resolution over single spheres at the cost of 0.2-0.4 attenuation in peak intensity of the central focused beam. Potential applications include ultra precise laser ablation or coagulation in the eye and brain, cellular surgery, and the coupling of light into photonic nanostructures.

摘要

利用数值光线追迹法研究了通过直接组装在空心波导芯内的介电微球链对多模光束的聚焦。这些器件设计针对与强吸收组织接触模式下的激光手术进行了优化。通过分析广泛的参数表明,由三个或五个折射率为1.65 - 1.75的球体形成的链在空间分辨率上比单个球体提高了两倍,代价是中心聚焦光束的峰值强度衰减0.2 - 0.4。潜在应用包括眼睛和大脑中的超精确激光消融或凝固、细胞手术以及光与光子纳米结构的耦合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c20c/3368307/5bf63691a096/oe-19-4-3440-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c20c/3368307/0c714fda128d/oe-19-4-3440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c20c/3368307/d0cca238b3e6/oe-19-4-3440-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c20c/3368307/22c6f20806bb/oe-19-4-3440-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c20c/3368307/5bf63691a096/oe-19-4-3440-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c20c/3368307/0c714fda128d/oe-19-4-3440-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c20c/3368307/d0cca238b3e6/oe-19-4-3440-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c20c/3368307/22c6f20806bb/oe-19-4-3440-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c20c/3368307/5bf63691a096/oe-19-4-3440-g004.jpg

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本文引用的文献

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