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现行多价抗蛇毒血清不足 - 来自喀拉拉邦中部的研究。

Inadequacy of present polyspecific anti snakevenom - a study from central Kerala.

机构信息

Department of Pediatrics, Government Medical College, Kottayam, Kerala, India.

出版信息

Indian J Pediatr. 2011 Oct;78(10):1225-8. doi: 10.1007/s12098-011-0396-y. Epub 2011 Mar 3.

Abstract

OBJECTIVES

To study the cause for prolonged coagulation profile and death in properly treated hemotoxic snake envenomation and the bad prognostic indicators in snake envenomation.

METHODS

This was a hospital based prospective analytical study. All snake bites with envenomation from 2006 through 2009 were clinically analysed at the time of admission. They were treated with standard treatment protocol. Snakes brought were preserved, identified and correlated with clinical details.

RESULTS

Of the 73 envenomation patients registered, 66 (90.4%) were hemotoxic envenomation, in which 14 (19.2%) had late recovery and 11 (15.1%) expired mainly due to hemorrhagic complication. The incidence of late recovery and mortality is higher compared to other Indian studies. Ten snakes were brought during the period along with the victims. Three of them were identified as hump nosed pit vipers, of which two victims had late recovery and one expired.

CONCLUSIONS

Hump nosed pit viper envenomation is not rare in Kerala and can cause death, unlike the earlier belief. Available anti snake venoms does not cover pit viper. So, antivenom for this snake is urgently required.

摘要

目的

研究经适当治疗的血液毒素性蛇咬伤导致凝血时间延长和死亡的原因,以及蛇咬伤的不良预后指标。

方法

这是一项基于医院的前瞻性分析研究。在入院时对 2006 年至 2009 年期间所有发生蛇咬伤中毒的患者进行临床分析。所有患者均采用标准治疗方案进行治疗。保存并识别送来的蛇,并将其与临床详细信息相关联。

结果

在登记的 73 例蛇咬伤中毒患者中,66 例(90.4%)为血液毒素性蛇咬伤,其中 14 例(19.2%)出现迟发性恢复,11 例(15.1%)主要因出血并发症而死亡。与其他印度研究相比,迟发性恢复和死亡率更高。在此期间,有 10 条蛇与受害者一起送来。其中 3 条被鉴定为吻突棱鼻蛇,其中 2 例出现迟发性恢复,1 例死亡。

结论

在喀拉拉邦,吻突棱鼻蛇咬伤并不罕见,可能导致死亡,这与之前的观点不同。现有的抗蛇毒血清并不能覆盖棱鼻蛇,因此急需针对这种蛇的抗蛇毒血清。

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