Meena Laxman S
CSIR-Institute of Genomics and Integrative Biology, Delhi 110 007, India,
J Biosci. 2019 Mar;44(1).
In today's era tuberculosis is a major threat to human population. The lethality of this disease is caused by very efficiently thrived bacteria . Ca plays crucial role in maintenance of cellular homeostasis. Bacilli survival in human alveolar macrophages majorly depends on disruption in Ca signaling. Bacilli sustainability in phagosome lies in the interruption of phagolysosomal fusion, which is possible because of low intracellular Ca concentration. Bacilli contain various Ca binding proteins which help in regulation of Ca signaling for its own benefit. For the survival of pathogen, it requires alteration in normal Ca concentration in healthy cell. In this review we aim to find the various Ca binding domains which are present in several Ca binding proteins of and variety of roles played by Ca to survive bacilli within host cell. This manuscript emphasizes the Ca binding domains present in PE_PGRS group of gene family and their functionality in survival and pathogenesis.
在当今时代，结核病是对人类的重大威胁。这种疾病的致死性是由高效繁殖的细菌引起的。钙在维持细胞内稳态中起着关键作用。杆菌在人类肺泡巨噬细胞中的存活主要取决于钙信号的破坏。杆菌在吞噬体中的可持续性在于吞噬溶酶体融合的中断，这是由于细胞内钙浓度低而可能发生的。杆菌含有多种钙结合蛋白，这些蛋白有助于调节钙信号以自身受益。为了病原体的存活，它需要改变健康细胞中的正常钙浓度。在这篇综述中，我们旨在找到存在于几种钙结合蛋白中的各种钙结合结构域，以及钙在宿主细胞内使杆菌存活所起的各种作用。本手稿强调了基因家族PE_PGRS组中存在的钙结合结构域及其在杆菌存活和发病机制中的功能。
