钯催化 2-甲基氮杂芳烃的苄基芳基化反应。
Palladium-catalyzed benzylic arylation of 2-methyl azaarenes.
机构信息
Syngenta Ltd., Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK.
出版信息
Org Lett. 2010 Dec 3;12(23):5359-61. doi: 10.1021/ol102276e. Epub 2010 Nov 2.
PMID:21043493
Abstract
A palladium-catalyzed benzylic sp(3) direct arylation of electron-deficient heterocycles is reported. The method described enables the introduction of electron-rich and -poor aromatics at the benzylic position of heterocycles without the need for preactivation or the use of directing groups.
摘要
报道了一种钯催化的缺电子杂环的苄位 sp(3)直接芳基化反应。该方法可以在杂环的苄位引入富电子和缺电子的芳基，而不需要预活化或使用导向基团。
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