Wilcox G M, Aretz H T, Roy M A, Roche J K
Department of Gastroenterology, Lahey Clinic Medical Center, Burlington, Massachusetts.
Gastroenterology. 1990 Mar;98(3):786-91.
We report the case of an 18-yr-old man with quiescent ulcerative colitis complicated by concomitant primary sclerosing cholangitis and rapidly progressive glomerulonephritis. Findings on immunofluorescence microscopy and electron microscopy suggested that glomerular injury occurred secondary to the deposition of circulating immune complexes. Renal disease responded to treatment with corticosteroids. A review of the literature found similar cases of glomerulonephritis and inflammatory bowel disease, but no previous association with sclerosing cholangitis has been recognized. The pertinent clinical, immunological, and pathophysiological aspects of this association are reviewed.
我们报告了一例18岁男性病例，其静止期溃疡性结肠炎并发原发性硬化性胆管炎和快速进展性肾小球肾炎。免疫荧光显微镜检查和电子显微镜检查结果提示，肾小球损伤继发于循环免疫复合物的沉积。肾脏疾病对皮质类固醇治疗有反应。文献回顾发现了肾小球肾炎与炎症性肠病的类似病例，但此前未认识到与硬化性胆管炎有关联。本文对这种关联的相关临床、免疫学和病理生理学方面进行了综述。
