Wilkins T D, Cossart Y E
Department of Infectious Diseases, University of Sydney, NSW.
Med J Aust. 1990 Feb 5;152(3):140-3. doi: 10.5694/j.1326-5377.1990.tb125121.x.
In 454 medical and dental students who were vaccinated against hepatitis B by means of a low dose (0.1 mL) of serum-derived vaccine, seroconversion rates of 27%, 70% and 89% were obtained after the first, second and third doses, respectively. These figures are comparable with the results that have been reported for the conventional intramuscular schedule, as were the final antibody titres. A fourth intradermal dose boosted the percentage of students who were protected from 82% to 87%. There was a significant variation in the response to different batches of vaccine. This study shows that the low-dose intradermal method is practicable and effective and can be used to achieve great economy in hepatitis B vaccination programmes. The possibility of adding hepatitis B to the present formula of triple antigen should be investigated as a way of extending hepatitis B vaccination to all infants in our community.
在454名接受低剂量（0.1毫升）血清源性疫苗接种乙肝疫苗的医学和牙科学生中，第一、第二和第三剂接种后的血清转化率分别为27%、70%和89%。这些数字与传统肌肉注射方案所报告的结果相当，最终抗体滴度也是如此。第四剂皮内注射将受到保护的学生比例从82%提高到了87%。对不同批次疫苗的反应存在显著差异。本研究表明，低剂量皮内接种方法可行且有效，可用于在乙肝疫苗接种计划中实现巨大的经济效益。应研究将乙肝疫苗添加到目前三联抗原配方中的可能性，以此作为将乙肝疫苗接种扩展到我们社区所有婴儿的一种方式。
