调节 T 辅助细胞中的 Il9 转录。
Regulating Il9 transcription in T helper cells.
机构信息
School of Informatics, Indiana University-Purdue University Indianapolis, IN 46202, USA.
出版信息
Trends Immunol. 2011 Apr;32(4):146-50. doi: 10.1016/j.it.2011.01.006. Epub 2011 Mar 2.
Abstract
T helper (Th) cells are crucial for the development of immunity to infections and inflammatory disease. The acquisition of specific cytokine-secreting profiles, primed by the cytokine microenvironment, is required for effector function of Th cells. The most recent addition to the growing list of effector subsets are Th9 cells that secrete IL-9. In this review, we propose a model for the transcriptional regulation of the Il9 gene in IL-9-expressing T cells and the relatedness of this subset to other Th phenotypes. We suggest that transcription factors restricted to certain Th subsets and common among several subsets might play a role in the plasticity of Th9 cells.
摘要
辅助性 T 细胞（Th）对于感染和炎症性疾病的免疫发展至关重要。Th 细胞的效应功能需要通过细胞因子微环境预先确定特定的细胞因子分泌特征。在不断增加的效应亚群中，最新增加的是分泌白细胞介素 9（IL-9）的 Th9 细胞。在这篇综述中，我们提出了一个在表达 IL-9 的 T 细胞中 Il9 基因转录调控的模型，以及该亚群与其他 Th 表型的相关性。我们认为，仅限于某些 Th 亚群的转录因子，以及在几个亚群中常见的转录因子，可能在 Th9 细胞的可塑性中发挥作用。
相似文献
1
Regulating Il9 transcription in T helper cells.调节 T 辅助细胞中的 Il9 转录。
Trends Immunol. 2011 Apr;32(4):146-50. doi: 10.1016/j.it.2011.01.006. Epub 2011 Mar 2.
2
Th9 cells: differentiation and disease.Th9 细胞：分化与疾病
Immunol Rev. 2013 Mar;252(1):104-15. doi: 10.1111/imr.12028.
3
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus.STAT5 促进可及性，并在 Il9 基因座的 BATF 介导的可塑性中起作用。
Nat Commun. 2020 Sep 28;11(1):4882. doi: 10.1038/s41467-020-18648-6.
4
The symphony of the ninth: the development and function of Th9 cells.第九交响乐：Th9 细胞的发育和功能。
Curr Opin Immunol. 2012 Jun;24(3):303-7. doi: 10.1016/j.coi.2012.02.001. Epub 2012 Feb 22.
5
BCL6 controls Th9 cell development by repressing Il9 transcription.BCL6 通过抑制 Il9 转录来控制 Th9 细胞的发育。
J Immunol. 2014 Jul 1;193(1):198-207. doi: 10.4049/jimmunol.1303184. Epub 2014 May 30.
6
The transcription factor network in Th9 cells.Th9细胞中的转录因子网络。
Semin Immunopathol. 2017 Jan;39(1):11-20. doi: 10.1007/s00281-016-0600-2. Epub 2016 Nov 11.
7
A conserved enhancer regulates Il9 expression in multiple lineages.一个保守的增强子调控多种谱系中的 Il9 表达。
Nat Commun. 2018 Nov 15;9(1):4803. doi: 10.1038/s41467-018-07202-0.
8
Alkaline Cytosolic pH and High Sodium Hydrogen Exchanger 1 (NHE1) Activity in Th9 Cells.Th9细胞中的碱性胞质pH值与高钠氢交换体1（NHE1）活性
J Biol Chem. 2016 Nov 4;291(45):23662-23671. doi: 10.1074/jbc.M116.730259. Epub 2016 Sep 14.
9
Transcriptional Control of Th9 Cells: Role of Foxo1 in Interleukin-9 Induction.Th9 细胞的转录调控：Foxo1 在白细胞介素-9 诱导中的作用。
Front Immunol. 2018 May 9;9:995. doi: 10.3389/fimmu.2018.00995. eCollection 2018.
10
Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of T9 cells programmed by IL-7.Foxo1 和 Foxp1 在调节由 IL-7 编程的 T9 细胞分化和抗肿瘤活性方面发挥着相反的作用。
Sci Signal. 2017 Oct 10;10(500):eaak9741. doi: 10.1126/scisignal.aak9741.
引用本文的文献
1
Loss of YTHDF2 enhances Th9 programming and CAR-Th9 cell antitumor efficacy.YTHDF2的缺失增强了Th9细胞的分化编程及CAR-Th9细胞的抗肿瘤功效。
Nat Immunol. 2025 Aug 18. doi: 10.1038/s41590-025-02235-2.
2
Exploring the role of the Th9/IL-9 axis in atopic dermatitis: analysis of Th9 cells, PU.1 expression and serum IL-9 levels.探索Th9/IL-9轴在特应性皮炎中的作用：Th9细胞、PU.1表达及血清IL-9水平分析
Immunol Res. 2025 Jul 30;73(1):114. doi: 10.1007/s12026-025-09671-0.
3
Interventions in cytokine signaling: novel horizons for psoriasis treatment.细胞因子信号传导干预：银屑病治疗的新视野
Front Immunol. 2025 Apr 15;16:1573905. doi: 10.3389/fimmu.2025.1573905. eCollection 2025.
4
GITRL enhances cytotoxicity and persistence of CAR-T cells in cancer therapy.在癌症治疗中，糖皮质激素诱导的肿瘤坏死因子受体家族相关蛋白（GITRL）增强了嵌合抗原受体T细胞（CAR-T）的细胞毒性和持久性。
Mol Ther. 2025 Jun 4;33(6):2789-2800. doi: 10.1016/j.ymthe.2025.01.036. Epub 2025 Jan 25.
5
Differentiation and regulation of CD4 T cell subsets in Parkinson's disease.帕金森病中 CD4 T 细胞亚群的分化与调控。
Cell Mol Life Sci. 2024 Aug 17;81(1):352. doi: 10.1007/s00018-024-05402-0.
6
Oligomeric amyloid beta prevents myelination in a clusterin-dependent manner.寡聚淀粉样β蛋白以一种依赖簇集蛋白的方式阻止髓鞘形成。
Res Sq. 2024 May 30:rs.3.rs-4415143. doi: 10.21203/rs.3.rs-4415143/v1.
7
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma.TL1A 引发诱导产生多细胞因子 Th9 细胞表型，促进哮喘小鼠模型中强烈的过敏炎症反应。
Mucosal Immunol. 2024 Aug;17(4):537-553. doi: 10.1016/j.mucimm.2024.03.006. Epub 2024 Mar 15.
8
Regulatory role of T helper 9/interleukin-9: Transplantation view.辅助性T细胞9/白细胞介素-9的调节作用：移植视角
Heliyon. 2024 Feb 15;10(4):e26359. doi: 10.1016/j.heliyon.2024.e26359. eCollection 2024 Feb 29.
9
IL-9-Producing Th9 Cells Participate in the Occurrence and Development of Iodine-Induced Autoimmune Thyroiditis.IL-9 产生的 Th9 细胞参与碘诱导的自身免疫性甲状腺炎的发生和发展。
Biol Trace Elem Res. 2023 Nov;201(11):5298-5308. doi: 10.1007/s12011-023-03598-z. Epub 2023 Feb 11.
10
CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease.CD4 T 细胞亚群与炎症性肠病的病理生理学。
Int J Mol Sci. 2023 Jan 31;24(3):2696. doi: 10.3390/ijms24032696.
本文引用的文献
1
A brief history of IL-9.白细胞介素-9 的简史。
J Immunol. 2011 Mar 15;186(6):3283-8. doi: 10.4049/jimmunol.1003049.
2
The transcription factor STAT3 is required for T helper 2 cell development.转录因子 STAT3 是辅助性 T 细胞 2 发育所必需的。
Immunity. 2011 Jan 28;34(1):39-49. doi: 10.1016/j.immuni.2010.12.013. Epub 2011 Jan 6.
3
IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells.IFN-γ 和 IL-12 协同作用将体内产生的 Th17 转化为 Th1/Th17 细胞。
Eur J Immunol. 2010 Nov;40(11):3017-27. doi: 10.1002/eji.201040539.
4
Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.抗原特异性 Th9 细胞在细胞因子产生的动力学和在炎症部位的短暂滞留方面表现出独特性。
J Immunol. 2010 Dec 1;185(11):6795-801. doi: 10.4049/jimmunol.1001676. Epub 2010 Oct 22.
5
Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.在缺乏 TGF-β 信号的情况下生成致病性 T(H)17 细胞。
Nature. 2010 Oct 21;467(7318):967-71. doi: 10.1038/nature09447.
6
A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma.一种新型的 CD4(+) T(H)2 记忆/效应细胞亚群，其能够产生促炎的白介素-17 细胞因子，促进慢性过敏性哮喘的恶化。
J Exp Med. 2010 Oct 25;207(11):2479-91. doi: 10.1084/jem.20101376. Epub 2010 Oct 4.
7
Cellular sources and immune functions of interleukin-9.白细胞介素-9 的细胞来源和免疫功能。
Nat Rev Immunol. 2010 Oct;10(10):683-7. doi: 10.1038/nri2848. Epub 2010 Sep 17.
8
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.干扰素调节因子 4 是辅助性 T 细胞 9 发育程序所必需的。
Immunity. 2010 Aug 27;33(2):192-202. doi: 10.1016/j.immuni.2010.07.014. Epub 2010 Jul 30.
9
Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.Smad2 和 Smad3 在 TGF-β 介导的调节性 T 细胞可塑性和 Th1 细胞发育的调控中冗余地必不可少。
J Immunol. 2010 Jul 15;185(2):842-55. doi: 10.4049/jimmunol.0904100. Epub 2010 Jun 14.
10
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.细胞因子和转录因子基因座的表观遗传不稳定性是 Th17 细胞谱系可塑性的基础。
Immunity. 2010 May 28;32(5):616-27. doi: 10.1016/j.immuni.2010.04.016. Epub 2010 May 13.
Zotero 插件