Department of Clinical Cancer Prevention, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4009, USA.
Cancer Prev Res (Phila). 2011 Mar;4(3):296-8. doi: 10.1158/1940-6207.CAPR-11-0060.
Curcumin exhibits significant antitumorigenic activity in various preclinical models; data supporting its chemopreventive activity in humans, however, are lacking. To our knowledge, the first published results of a phase II chemoprevention study of curcumin are reported in this issue of the journal by Carroll and colleagues (beginning on page 354), who examined the effects of oral curcumin on various putative biomarkers of colonic tumorigenesis in smokers. This perspective discusses the potential significance and limitations of the current study findings in addressing the question of whether curcumin is clinically active as a chemopreventive agent.
姜黄素在各种临床前模型中表现出显著的抗肿瘤活性；然而，缺乏支持其在人类中具有化学预防活性的数据。据我们所知，卡罗尔及其同事在本期杂志上发表了姜黄素化学预防研究的首个 II 期研究结果（第 354 页开始），他们研究了口服姜黄素对吸烟者结肠肿瘤发生的各种潜在生物标志物的影响。本观点讨论了当前研究结果在回答姜黄素是否作为化学预防剂具有临床活性的问题方面的潜在意义和局限性。
