Department of Microbiology and Tumor Virology Program, Abramson, Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA.
Clin Cancer Res. 2011 May 15;17(10):3056-63. doi: 10.1158/1078-0432.CCR-10-2578. Epub 2011 Mar 3.
Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that establishes a life-long asymptomatic infection in immunocompetent hosts. It is also found to be frequently associated with a broad spectrum of B-cell lymphomas predominantly seen in immunodeficient patients. Despite many resemblances, these EBV-linked lymphoproliferative disorders display heterogeneity at the clinical and the molecular level. Moreover, EBV-associated lymphoproliferative diseases differ in their differential expression patterns of the EBV-encoded latent antigens, which are directly related to their interactions with the host. EBV-driven primary B-cell immortalization is linked to the cooperative functions of these latent proteins, which are critical for perturbing many important cell-signaling pathways maintaining B-cell proliferation. Additionally, it is used as a surrogate model to explore the underlying mechanisms involved in the development of B-cell neoplasms. Recent discoveries have revealed that a number of sophisticated mechanisms are exploited by EBV during cancer progression. This finding will be instrumental in the design of novel approaches for therapeutic interventions against EBV-associated B-cell lymphomas. This review limits the discussion to the biology and pathogenesis of EBV-associated B-cell lymphomas and the related clinical implications.
EB 病毒（EBV）是一种广泛存在的人类γ疱疹病毒，在免疫功能正常的宿主中建立终身无症状感染。它也经常与广泛的 B 细胞淋巴瘤相关，主要见于免疫功能低下的患者。尽管有许多相似之处，但这些 EBV 相关的淋巴增殖性疾病在临床和分子水平上表现出异质性。此外，EBV 相关的淋巴增殖性疾病在 EBV 编码的潜伏抗原的表达模式上存在差异，这与它们与宿主的相互作用直接相关。EBV 驱动的原发性 B 细胞永生化与这些潜伏蛋白的协同功能有关，这些功能对于扰乱维持 B 细胞增殖的许多重要细胞信号通路至关重要。此外，它被用作探索 B 细胞肿瘤发生中涉及的潜在机制的替代模型。最近的发现表明，EBV 在癌症进展过程中利用了许多复杂的机制。这一发现将有助于设计针对 EBV 相关 B 细胞淋巴瘤的新型治疗干预方法。本文的讨论仅限于 EBV 相关 B 细胞淋巴瘤的生物学和发病机制及其相关的临床意义。
