Bricaire F, Hannoun C, Boissel J P
Service des Maladies infectieuses et tropicales, Hôpital Bichat-Claude-Bernard, Paris.
Presse Med. 1990 Jan 20;19(2):69-72.
The prophylactic effectiveness of rimantadine hydrochloride (RH) during an outbreak of influenza A was evaluated in a double-blind study versus placebo (P). After identification of 111 homes with one affected member, 301 household contacts were enrolled and given either RH (151 contacts from 56 households) or a placebo (150 contacts from 55 households). Each treatment was given for ten days. Overall, at least one contact developed influenza in 8 of the 56 RH group households and 19 of the 55 placebo group households (p = 0.013). Numbers of contacts who developed influenza were 8/151 in the RH group and 26/150 in the placebo group. When only the 49 homes where influenza was confirmed by virological studies were considered, these numbers were 4/28 in the RH group and 10/21 in the placebo group (p = 0.011). Adverse effects were seen in 18 of the 151 subjects given RH (11.9 per cent) and 6 of the 150 subjects given the placebo (4 per cent). RH appeared as an effective prophylactic agent in a confirmed influenza A outbreak and was satisfactorily tolerated.
在一项双盲研究中，对盐酸金刚烷胺（RH）与安慰剂（P）在甲型流感暴发期间的预防效果进行了评估。在确定了111户有一名成员感染的家庭后，招募了301名家庭接触者，并给予RH（来自56户家庭的151名接触者）或安慰剂（来自55户家庭的150名接触者）。每种治疗均持续10天。总体而言，56个RH组家庭中有8个家庭至少有一名接触者感染流感，55个安慰剂组家庭中有19个家庭出现这种情况（p = 0.013）。RH组中感染流感的接触者人数为8/151，安慰剂组为26/150。仅考虑通过病毒学研究确诊流感的49户家庭时，RH组的这一数字为4/28，安慰剂组为10/21（p = 0.011）。给予RH的151名受试者中有18名出现不良反应（11.9%），给予安慰剂的150名受试者中有6名出现不良反应（4%）。在确诊的甲型流感暴发中，RH表现为一种有效的预防药物，且耐受性良好。
