盐酸金刚乙胺长期给药在疗养院预防甲型流感病毒感染中的安全性。
Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes.
作者信息
Patriarca P A, Kater N A, Kendal A P, Bregman D J, Smith J D, Sikes R K
出版信息
Antimicrob Agents Chemother. 1984 Jul;26(1):101-3. doi: 10.1128/AAC.26.1.101.
Abstract
We evaluated the safety of rimantadine hydrochloride (RH) prophylaxis in a double-blind, placebo-controlled trial in three nursing homes during a community epidemic of influenza A (H3N2). Although daily monitoring of the 35 participants revealed an association between RH administration (100 mg twice a day) and the development of nausea and anxiety (P less than 0.05), these and other potential side effects were transient and were rarely considered to be clinically significant. Serum RH levels measured at the end of the trial (mean, 1,159 ng/ml) were nearly three times higher than those measured previously in younger individuals, suggesting that lower dosages may be indicated for the elderly.
摘要
在甲型（H3N2）流感社区流行期间，我们在三家养老院进行了一项双盲、安慰剂对照试验，评估了盐酸金刚烷胺（RH）预防用药的安全性。尽管对35名参与者的每日监测显示，服用RH（每日两次，每次100毫克）与恶心和焦虑的发生之间存在关联（P<0.05），但这些以及其他潜在副作用是短暂的，很少被认为具有临床意义。试验结束时测得的血清RH水平（平均为1159纳克/毫升）几乎是之前在较年轻个体中测得水平的三倍，这表明老年人可能需要较低剂量。
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