来自益智的新倍半萜和二萜。
New sesquiterpenoids and a diterpenoid from Alpinia oxyphylla.
作者信息
Hou Lei, Ding Gang, Guo Baolin, Huang Wenhua, Zhang Xiaojian, Sun Zhiyong, Shi Xiangfen
机构信息
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
出版信息
Molecules. 2015 Jan 16;20(1):1551-9. doi: 10.3390/molecules20011551.
The new compounds 2-methyl-6-isopropyl-7-hydroxymethyl naphthalene (1), oxyphyllenone H (2), epi-oxyphyllenone (6), (E)-labda-12,14-dien-15(16)-olide-17-oic acid (3), and two new natural products 4 and 5 were isolated from the ethyl acetate part of 95% ethanol extract of Alpinia oxyphylla, together with six known compounds 7-12. The inhibitory effects of compounds 1-12 on α-glucosidase were evaluated, and compounds 1, 3 and 6 showed moderate bioactive effect, with inhibitory rates of 10.3%, 10.0% and 11.5%, respectively, compared to the positive control acarbose (41.9%) at 20 µg/mL.
从益智95%乙醇提取物的乙酸乙酯部位分离得到新化合物2-甲基-6-异丙基-7-羟甲基萘（1）、氧叶烯酮H（2）、表氧叶烯酮（6）、（E）-喇叭茶-12,14-二烯-15（16）-内酯-17-酸（3）以及两个新天然产物4和5，同时还得到6个已知化合物7 - 12。评价了化合物1 - 12对α-葡萄糖苷酶的抑制作用，在20μg/mL时，化合物1、3和6表现出中等生物活性，抑制率分别为10.3%、10.0%和11.5%，与阳性对照阿卡波糖（41.9%）相比。
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