Department of Gastroenterology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Ishikawa 920-0293, Japan.
J Clin Biochem Nutr. 2011 Mar;48(2):167-9. doi: 10.3164/jcbn.09-119GFR. Epub 2010 Apr 10.
Although alcohol abuse is the most common cause of liver cirrhosis in the United States, the enhancing effects of alcohol on the long-term prognosis of hepatitis C virus (HCV) related liver cirrhosis has not been clarified. To investigate how alcohol abuse influences the prognosis of hepatitis virus related liver cirrhosis, we studied 716 Japanese patients. Cumulative survival and hepatocellular carcinoma (HCC) development rates were analyzed in alcohol abusive, cirrhotic patients with or without hepatitis virus infection. Patients who abused alcohol were younger (p<0.0001) than HCV infected, non-abusive patients. The overall survival rate among patients with alcoholic cirrhosis (Al group), HCV related cirrhosis (HCV group), and HCV infected + alcoholic cirrhosis (HCV + Al group), showed no significant differences, although the 10-year cumulative survival rate of Al group was the highest of the three groups. The HCC development rate of Al group was the lowest. In addition, alcohol abuse decreased the survival rates of HCV group in the early stage with no HCC (p = 0.0028). In conclusion, alcohol abuse might affect the progression of liver damage in HCV infected patients with liver cirrhosis in the early stage, although the influence of alcohol abuse on the long term prognosis seems to be rather small.
尽管酗酒在美国是导致肝硬化的最常见原因，但酒精对丙型肝炎病毒（HCV）相关肝硬化长期预后的增强作用尚未阐明。为了研究酗酒如何影响肝炎病毒相关肝硬化的预后，我们研究了 716 名日本患者。分析了酒精滥用、合并或不合并肝炎病毒感染的肝硬化患者的累积生存率和肝细胞癌（HCC）发展率。酗酒患者比 HCV 感染、非酗酒患者更年轻（p<0.0001）。酒精性肝硬化（Al 组）、HCV 相关肝硬化（HCV 组）和 HCV 感染+酒精性肝硬化（HCV+Al 组）患者的总体生存率无显著差异，尽管 Al 组的 10 年累积生存率是三组中最高的。Al 组的 HCC 发展率最低。此外，酒精滥用降低了早期无 HCC 的 HCV 组的生存率（p=0.0028）。总之，尽管酒精滥用对长期预后的影响似乎很小，但它可能会影响 HCV 感染合并肝硬化患者在早期阶段的肝损伤进展。
