Centre for Virology, Burnet Institute, 85 Commercial Road, Melbourne, VIC 3004, Australia.
J Neuroimmune Pharmacol. 2011 Jun;6(2):269-83. doi: 10.1007/s11481-011-9268-5. Epub 2011 Mar 5.
Intracellular signaling events are signposts of biological processes, which govern the direction and action of biological activities. Through millions of years of evolution, pathogens, such as viruses, have evolved to hijack host cell machinery to infect their targets and are therefore dependent on host cell signaling for replication. This review will detail our current understanding of the signaling events that are important for the early steps of HIV-1 replication. More specifically, the therapeutic potential of signaling events associated with chemokine coreceptors, virus entry, viral synapses, and post-entry processes will be discussed. We argue that these pathways may represent novel targets for antiviral therapy.
细胞内信号事件是生物过程的标志，它们控制着生物活动的方向和作用。经过数百万年的进化，病原体（如病毒）已经进化到劫持宿主细胞机制来感染它们的靶标，因此它们的复制依赖于宿主细胞信号。本综述将详细介绍我们目前对 HIV-1 复制早期步骤中重要的信号事件的理解。更具体地说，将讨论与趋化因子共受体、病毒进入、病毒突触和进入后过程相关的信号事件的治疗潜力。我们认为这些途径可能代表抗病毒治疗的新靶点。
