Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections, The Johns Hopkins University School of Medicine, Meyer 6-109, 600N. Wolfe Street, Baltimore, MD 21287, USA.
J Neuroimmune Pharmacol. 2011 Jun;6(2):284-95. doi: 10.1007/s11481-011-9274-7. Epub 2011 Mar 29.
Infection by the human immunodeficiency virus (HIV) involves a number of important interactions with lipid components in host membranes that regulate binding, fusion, internalization, and viral assembly. Available data suggests that HIV actively modifies the sphingolipid content of cellular membranes to create focal environments that are favorable for infection. In this review, we summarize the roles that membrane lipids play in HIV infection and discuss the current status of therapeutics that attempt to modify biological membranes to inhibit HIV.
人类免疫缺陷病毒(HIV)的感染涉及宿主膜中与脂质成分的一些重要相互作用,这些相互作用调节着病毒的结合、融合、内化和组装。现有数据表明,HIV 会主动修饰细胞膜中的神经鞘脂含量,以创造有利于感染的局部环境。在这篇综述中,我们总结了膜脂质在 HIV 感染中的作用,并讨论了试图修饰生物膜以抑制 HIV 的治疗方法的现状。