Bhatty Shaheen Ayuob, Shaikh Niaz Ahmed, Irfan Muhammad, Kashif Syed Muhammad, Vaswani Aneel Sham, Sumbhai Aneel
Medical Unit One, Civil Hospital Karachi.
J Pak Med Assoc. 2010 Nov;60(11):949-51.
To check the Vitamin D levels in patients diagnosed as fibromyagia in our population.
Study was done at Medical OPD of Civil Hospital Karachi, from January to March 2009. Female patients diagnosed as Fibromyalgia according to American College of Rheumatology (ACR) criteria and exclusion of systemic illness on examination, and normal reports of blood CP, ESR, serum calcium, phosphate and Alkaline Phosphatase, were asked to get Vitamin D levels in their serum. Vitamin D deficiency is defined as <20 ng/ml, Vitamin D insufficiency 21-29 ng/ml and Vitamin D sufficiency equal or >30 ng/ml.
Forty female patients were included in the study. The mean age was 37.65 +/- 11.5 years. Mean Vitamin D level was 17.41 +/- 5.497 ng/ml. Thirty two (80%) of patients had Vitamin D deficiency, mean levels of 15.855 +/- 4.918 ng/ml and 8(20%) had Vitamin D insufficiency, mean levels of 23.64 +/- 2.39 ng/ml. Patients with vitamin D deficiency and age less than 45 years were 22 (68.75%), had mean vitamin D level 16.87 +/- 4.48 ng/ml whereas in age ranging from 46-75 years were 10 (31.25%) had mean vitamin D level 16.09 +/- 6.45 ng/ml.
Vitamin D deficiency is frequently seen in patients diagnosed as fibromyalgia and nonspecific musculoskeletal pain in our population. Although the sample size of the study is small, but the figures are so alarming that it is an eye opener towards the need of a population based study, including normal population as well as those presenting with musculoskeletal pain.
检测我院确诊为纤维肌痛患者的维生素D水平。
于2009年1月至3月在卡拉奇市民医院内科门诊进行研究。根据美国风湿病学会（ACR）标准诊断为纤维肌痛且经检查排除全身性疾病、血CP、ESR、血清钙、磷及碱性磷酸酶报告正常的女性患者，被要求检测血清维生素D水平。维生素D缺乏定义为<20 ng/ml，维生素D不足为21 - 29 ng/ml，维生素D充足为等于或>30 ng/ml。
40名女性患者纳入研究。平均年龄为37.65±11.5岁。平均维生素D水平为17.41±5.497 ng/ml。32例（80%）患者存在维生素D缺乏，平均水平为15.855±4.918 ng/ml；8例（20%）患者存在维生素D不足，平均水平为23.64±2.39 ng/ml。年龄小于45岁的维生素D缺乏患者有22例（68.75%），平均维生素D水平为16.87±4.48 ng/ml；年龄在46 - 75岁之间维生素D缺乏患者有10例（31.25%），平均维生素D水平为16.09±6.45 ng/ml。
在我院确诊为纤维肌痛及非特异性肌肉骨骼疼痛的患者中，维生素D缺乏较为常见。尽管本研究样本量较小，但这些数据令人警醒，提示有必要开展基于人群的研究，包括正常人群以及出现肌肉骨骼疼痛的人群。
