Department of Neurology, Unidad de Investigación Médica en Epidemiología Clínica, Hospital General de Zona UMF No. 1 IMSS, Colima, México.
Arch Med Res. 2011 Jan;42(1):44-7. doi: 10.1016/j.arcmed.2011.01.009.
Activation of histamine H3 receptors blocks the release of peptides responsible for headache. Our objective was to investigate the association between the genotypes of A280V polymorphism in the H3 receptor and migraine risk.
We evaluated the frequency of the genotypes of A280V, polymorphism A280V and allelic variants of H3 receptor in 147 migraine patients and 186 healthy controls using a PCR-RLFP method.
V allele frequency was 6.46% and 2.68% for the cases and controls, respectively (p = 0.02) (OR 2.67; 95% CI 1.20-5.93). The frequency of V/V + V/A genotypes was 12.92% in migraine patients, significantly higher when compared to the 3.22% frequency in the control group (p = 0.001) (OR 4.45; 95% CI 1.7-11.46).
The results of this study suggest that V-allele genotypes in the H3 receptor gene are related to migraine risk in the Mexican population. We propose the hypothesis that the V-allele genotypes in the H3 receptor gene increase the population of inactive receptors, enhancing the inhibition of the negative feedback mechanism on the H3 receptor and increasing histamine release, which correlates with migraine attacks in susceptible patients. The case-control study reinforces the role of histamine in migraine pathogenesis.
组胺 H3 受体的激活可阻断引起头痛的肽类物质的释放。我们的目的是研究 H3 受体 A280V 多态性的基因型与偏头痛风险之间的关联。
我们采用 PCR-RLFP 方法，评估了 147 例偏头痛患者和 186 例健康对照者中 H3 受体 A280V 多态性 A280V 基因型和等位基因变异的频率。
病例组和对照组的 V 等位基因频率分别为 6.46%和 2.68%（p=0.02）（OR 2.67；95%CI 1.20-5.93）。偏头痛患者中 V/V+V/A 基因型的频率为 12.92%，明显高于对照组的 3.22%（p=0.001）（OR 4.45；95%CI 1.7-11.46）。
本研究结果提示 H3 受体基因中的 V 等位基因与墨西哥人群的偏头痛风险相关。我们提出假设，H3 受体基因中的 V 等位基因基因型增加了无活性受体的数量，增强了 H3 受体负反馈机制的抑制作用，增加了组胺的释放，这与易感患者的偏头痛发作有关。病例对照研究强化了组胺在偏头痛发病机制中的作用。
