抗苗勒管激素、年龄与卵母细胞数的相关性：巴西体外受精中心的回顾性研究。
Correlation between anti-Müllerian hormone, age, and number of oocytes: A retrospective study in a Brazilian in vitro fertilization center.
机构信息
Faculdade de Medicina, Pontifícia Universidade Católica Curitiba, Paraná, Brazil.
Faculdade de Medicina, Faculdade Evangélica Mackenzie, Curitiba, Paraná, Brazil.
出版信息
JBRA Assist Reprod. 2022 Apr 17;26(2):214-221. doi: 10.5935/1518-0557.20210083.
OBJECTIVE
Is the AMH level correlated with age and number of mature oocytes retrieved from stimulated cycles?
METHODS
This descriptive, retrospective, observational study included the data of about 1500 patients submitted to Assisted Reproductive Technology treatments in a clinic in Brazil between July 2012 and April 2019. Patients not submitted to IVF and/or without AMH level records were excluded. The study included women with fertility issues aged 20-50 years submitted to IVF. A total of 733 patients were included. The patients were divided by age into three groups (≤35 years old; 36-39 years old; ≥40 years old).
RESULTS
The mean AMH concentration ranged from 2.65 to 1.35 ng/mL and was significantly different between the groups. The mean total number of retrieved oocytes ranged from 9.5 to 5.42 and was significantly different between the groups. The mean number of mature oocytes ranged from 7.14 to 4.58. There was no significant difference in the number of mature oocytes between patients aged 36-39 years and ≥40 years. Negative correlations were observed between patient age and total number of retrieved oocytes (-0.3354) and number of mature oocytes (-0.2839). AMH was negatively correlated with age (-0.3257), although positive correlations with total number of oocytes (0.6702) and number of mature oocytes (0.5770) were observed.
CONCLUSIONS
This is the largest study performed with Brazilian patients to correlate AMH levels, age, number of oocytes, and number of mature oocytes from controlled ovarian stimulation cycles. Our data showed that as age increases, AMH levels, number of retrieved oocytes, and number of mature oocytes decrease significantly. However, no significant difference in number of mature oocytes was observed when patients aged 36-39 and ≥40 years were compared. In addition, a positive correlation was found between serum AMH levels and total number of retrieved and mature oocytes from stimulated cycles.
目的
抗缪勒管激素（AMH）水平是否与年龄和刺激周期中成熟卵母细胞的数量有关？
方法
这是一项描述性、回顾性、观察性研究，纳入了 2012 年 7 月至 2019 年 4 月期间在巴西一家诊所接受辅助生殖技术治疗的约 1500 名患者的数据。排除未接受 IVF 治疗和/或无 AMH 水平记录的患者。该研究纳入了年龄在 20-50 岁之间、有生育问题的接受 IVF 的女性。共纳入 733 名患者。根据年龄将患者分为三组（≤35 岁；36-39 岁；≥40 岁）。
结果
AMH 浓度的平均值范围为 2.65-1.35ng/ml，组间差异有统计学意义。获卵总数的平均值范围为 9.5-5.42，组间差异有统计学意义。成熟卵母细胞的平均数量范围为 7.14-4.58。36-39 岁和≥40 岁患者的成熟卵母细胞数量无显著差异。患者年龄与获卵总数（-0.3354）和成熟卵母细胞数量（-0.2839）呈负相关。AMH 与年龄呈负相关（-0.3257），但与卵母细胞总数（0.6702）和成熟卵母细胞数量（0.5770）呈正相关。
结论
这是一项针对巴西患者进行的最大规模研究，旨在将 AMH 水平、年龄、促排卵周期中的卵子数量和成熟卵子数量进行相关性分析。我们的数据显示，随着年龄的增长，AMH 水平、获卵总数和成熟卵母细胞数量显著下降。然而，当比较 36-39 岁和≥40 岁的患者时，成熟卵母细胞数量无显著差异。此外，血清 AMH 水平与刺激周期中获卵总数和成熟卵母细胞数量呈正相关。
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