冠状动脉粥样硬化斑块生长的计算机模拟。
Computer simulations of atherosclerotic plaque growth in coronary arteries.
作者信息
Liu Biyue, Tang Dalin
机构信息
Department of Mathematics, Monmouth University, West Long Branch, NJ 07764, USA.
出版信息
Mol Cell Biomech. 2010 Dec;7(4):193-202.
Abstract
A three dimensional mathematical model with a linear plaque growth function was developed to investigate the geometrical adaptation of atherosclerotic plaques in coronary arteries and study the influences of flow wall shear stress (WSS), blood viscosity and the inlet flow rate on the growth of atherosclerotic plaques using computational plaque growth simulations. The simulation results indicated that the plaque wall thickness at the neck of the stenosis increased at a decreasing rate in the atherosclerosis progression. The simulation results also showed a strong dependence of the plaque wall thickness increase on the blood viscosity and the inlet flow rate. The progression rate in a coronary artery was lower with a higher inlet velocity flow rate and higher with a smaller value of the blood viscosity.
摘要
建立了具有线性斑块生长函数的三维数学模型，以研究冠状动脉中动脉粥样硬化斑块的几何适应性，并通过计算斑块生长模拟来研究血流壁面剪应力（WSS）、血液粘度和入口流速对动脉粥样硬化斑块生长的影响。模拟结果表明，在动脉粥样硬化进展过程中，狭窄处颈部的斑块壁厚度以递减的速率增加。模拟结果还显示，斑块壁厚度的增加强烈依赖于血液粘度和入口流速。冠状动脉中的进展速率在入口流速较高时较低，在血液粘度值较小时较高。
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