Rauch A L, Callahan M F, Buckalew V M, Morris M
Department of Medicine/Nephrology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
Am J Physiol. 1990 Feb;258(2 Pt 2):R531-5. doi: 10.1152/ajpregu.1990.258.2.R531.
The anterior ventral region of the third ventricle (AV3V) is a major central site in the regulation of cardiovascular and renal function. To examine the role of the central nervous system in the regulation of atrial natriuretic peptide (ANP) secretion, the effect of lesions in this region on basal, volume-stimulated, and osmotic-stimulated plasma ANP was determined. Basal levels of plasma ANP were not different in sham- and AV3V-lesioned rats. Volume expansion with a continuous infusion of saline or with a bolus administration of saline increased plasma ANP in sham-lesioned rats. In AV3V-lesioned rats, continuous infusion of saline had no effect on plasma ANP, and a bolus administration of saline decreased plasma ANP. Osmotic stimulation with hypertonic saline increased plasma ANP in sham-lesioned rats but had no effect on plasma ANP in AV3V-lesioned rats. These results suggest that the central nervous system is involved in the regulation of ANP secretion and that altered ANP regulation may contribute to the cardiovascular and renal deficiencies in AV3V-lesioned rats.
第三脑室前腹侧区（AV3V）是调节心血管和肾功能的主要中枢部位。为了研究中枢神经系统在心房利钠肽（ANP）分泌调节中的作用，测定了该区域损伤对基础、容量刺激和渗透刺激下血浆ANP的影响。假手术组和AV3V损伤组大鼠的血浆ANP基础水平无差异。持续输注生理盐水或推注生理盐水进行容量扩张可使假手术组大鼠的血浆ANP升高。在AV3V损伤的大鼠中，持续输注生理盐水对血浆ANP无影响，而推注生理盐水则使血浆ANP降低。用高渗盐水进行渗透刺激可使假手术组大鼠的血浆ANP升高，但对AV3V损伤组大鼠的血浆ANP无影响。这些结果表明，中枢神经系统参与了ANP分泌的调节，并且ANP调节的改变可能导致AV3V损伤大鼠的心血管和肾脏功能缺陷。
