Department of Toxicology, Faculty of Pharmacy, Ege University, Bornova, Izmir, Turkey.
Arch Pharm Res. 2011 Feb;34(2):253-9. doi: 10.1007/s12272-011-0211-3. Epub 2011 Mar 6.
Celecoxib is increasingly being used in children with rheumatologic complaints. Although the particular concerns about the safety of the drug, there are only a small number of published studies in children. This study was performed to investigate the effects of celecoxib on oxidative stress and antioxidant enzyme activities as well as celecoxib-induced changes in liver, kidneys and stomach of young rats. Four weeks-old Wistar albino, female rats were used. Celecoxib was given by gavage for 14 days. Control rats received only vehicle. Blood and organs were taken under pentobarbital anesthesia. Plasma malondialdehyde levels were increased by treatment. Catalase activity was increased, while glutathione peroxidase activity was decreased. Superoxide dismutase and glucose-6-phosphate dehydrogenase activities was not changed by treatment. The reduced glutathione content of kidneys were higher, while there was no significant difference in liver content, as compared with controls. Significant changes were observed in serum parameters of rats treated with celecoxib. Histopathological evaluation of organs was done by an experienced pathologist unaware of the treatment. Results of the present study indicated the alterations of oxidant/antioxidant status and histopathological changes in tissues of young rats treated with celecoxib.
塞来昔布在有风湿性疾病的儿童中越来越多地被使用。尽管人们特别关注该药物的安全性，但在儿童中只有少数已发表的研究。本研究旨在研究塞来昔布对氧化应激和抗氧化酶活性的影响，以及塞来昔布对幼年大鼠肝脏、肾脏和胃的影响。使用 4 周龄的 Wistar 白化雌性大鼠。塞来昔布通过灌胃给药 14 天。对照组大鼠仅给予载体。戊巴比妥麻醉下取血和器官。治疗后血浆丙二醛水平升高。过氧化氢酶活性增加，而谷胱甘肽过氧化物酶活性降低。超氧化物歧化酶和葡萄糖-6-磷酸脱氢酶的活性不受治疗影响。与对照组相比，肾脏的还原型谷胱甘肽含量较高，而肝脏含量没有显著差异。用塞来昔布治疗的大鼠的血清参数发生了显著变化。由一位不了解治疗方法的经验丰富的病理学家对器官进行组织学评估。本研究结果表明，塞来昔布治疗的幼年大鼠的氧化应激/抗氧化状态和组织学变化。
