Gastroenterological Center, Yokohama City University Medical Center, Minami-ku, Yokohama-shi, Kanagawa-ken, Japan.
J Surg Oncol. 2011 Aug 1;104(2):205-9. doi: 10.1002/jso.21906. Epub 2011 Mar 4.
Regenerating islet-derived family members (Reg) are superfamily of calcium-dependant lectins that are expressed in the proximal gastrointestinal tract and ectopically at other sites in the setting of tissue injury. The regenerating islet-derived family member 4 (RegIV) gene has been reported in various cancers, associating with diverse functions. This study examined the relation of the relative expression of RegIV gene to clinicopathological factors and outcomes in patients with colorectal cancer (CRC).
We studied surgical specimens of cancer tissue and adjacent normal mucosa obtained from 202 patients with untreated CRC. The relative expression levels of RegIV mRNA in cancer and in normal adjacent mucosa were measured by quantitative real-time reverse-transcriptase polymerase chain reaction.
RegIV gene expression was higher in cancer tissue than in adjacent normal mucosa. The multivariate analysis of clinicopathological factors for 5-year overall survival showed a higher level of RegIV gene expression was a significant independent predictor. Overall survival at 5 years differed significantly between patients with high RegIV gene expression and those with low expression.
Overexpression of the RegIV gene is considered a useful independent predictor of outcomes in patients with CRC.
再生胰岛衍生家族成员（Reg）是钙依赖性凝集素的超家族，在近端胃肠道表达，并在组织损伤的其他部位异位表达。再生胰岛衍生家族成员 4（RegIV）基因已在各种癌症中报道，与多种功能相关。本研究探讨了 RegIV 基因的相对表达与结直肠癌（CRC）患者临床病理因素和结局的关系。
我们研究了 202 例未经治疗的 CRC 患者的手术标本中的癌组织和相邻正常黏膜。通过定量实时逆转录聚合酶链反应测量癌症和正常相邻黏膜中 RegIV mRNA 的相对表达水平。
RegIV 基因在癌组织中的表达高于相邻正常黏膜。对 5 年总生存率的临床病理因素的多变量分析显示，RegIV 基因表达水平较高是一个显著的独立预测因子。高 RegIV 基因表达和低表达患者的 5 年总生存率有显著差异。
RegIV 基因的过表达被认为是 CRC 患者结局的一个有用的独立预测因子。
