Department of Physiology, University of Karachi, Karachi, Pakistan.
Al-Tibri Medical College and Hospital, Isra University Karachi Campus, Karachi, Pakistan.
Sci Rep. 2023 Dec 27;13(1):23002. doi: 10.1038/s41598-023-48402-z.
In recent years, the global prevalence of obesity and its associated metabolic disorders has reached alarming levels, presenting a significant challenge to public health worldwide. Visfatin, also known as pre-B cell colony-enhancing factor (PBEF) or nicotinamide phosphoribosyltransferase (NAMPT), is an adipokine that has been implicated in various physiological processes, including glucose homeostasis, lipid metabolism, and inflammation. The main objective of this proposed study is to find out the association between visfatin genetic variants and metabolic syndrome. The sample size of the study consisted of 300 blood samples (150 control and 150 cases). This study found that the genotypic frequency of visfatin SNPs, including rs2302559 (OD: 18.222; 95% CI 10.228-32.466; p-value < 0.001) and rs1215113036 (OD: 129.40; 95% CI 44.576-375.693; p-value < 0.001) were significantly associated with metabolic syndrome. Moreover, the frequency of the mutant alleles of both visfatin SNPs was found to be higher in patients with metabolic syndrome as compared to controls. Results of the current study indicate that people with any genetic variation of Visfatin, such as rs2302559 and rs1215113036, are more likely to develop metabolic syndrome. Visfatin genetic variants are linked to an increased risk of metabolic syndrome, implying it's role in disease pathophysiology.
近年来，肥胖及其相关代谢紊乱在全球的流行率已经达到了令人担忧的水平，对全球公共卫生构成了重大挑战。内脏脂肪素，也称为前 B 细胞集落增强因子（PBEF）或烟酰胺磷酸核糖基转移酶（NAMPT），是一种脂肪因子，与多种生理过程有关，包括葡萄糖稳态、脂质代谢和炎症。本研究的主要目的是探讨内脏脂肪素遗传变异与代谢综合征之间的关系。该研究的样本量包括 300 份血样（150 份对照和 150 份病例）。研究发现，内脏脂肪素 SNP 的基因型频率，包括 rs2302559（比值比：18.222；95%置信区间：10.228-32.466；p 值<0.001）和 rs1215113036（比值比：129.40；95%置信区间：44.576-375.693；p 值<0.001）与代谢综合征显著相关。此外，与对照组相比，代谢综合征患者两种内脏脂肪素 SNP 的突变等位基因频率更高。本研究结果表明，携带内脏脂肪素基因变异，如 rs2302559 和 rs1215113036 的个体，更容易发生代谢综合征。内脏脂肪素遗传变异与代谢综合征风险增加相关，提示其在疾病病理生理学中的作用。
