（±）-麦斯卡林的全合成。
Total synthesis of (±)-meloscine.
机构信息
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
出版信息
Org Lett. 2011 Apr 1;13(7):1778-80. doi: 10.1021/ol200311y. Epub 2011 Mar 7.
PMID:21381682
Abstract
The total synthesis of (±)-meloscine was completed in a highly stereoselective manner starting from the known 4-(2-aminophenyl)-2,3-dihydro-N-methoxycarbonylpyrrole. The crucial step in this total synthesis involves the efficient construction of the tetracyclic framework of the target natural product by the intramolecular Pauson-Khand reaction.
摘要
（±）-麦罗辛的全合成是从已知的 4-(2-氨基苯基)-2,3-二氢-N-甲氧羰基吡咯出发，以高度立体选择性的方式完成的。这个全合成的关键步骤涉及到通过分子内 Pauson-Khand 反应有效地构建目标天然产物的四环骨架。
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