PG and Research Department of Physics, Jamal Mohamed College (Autonomous), Tiruchirappalli - 620020, Tamilnadu, India.
Technol Cancer Res Treat. 2011 Apr;10(2):153-61. doi: 10.7785/tcrt.2012.500190.
Stokes Shift (SS) Spectroscopy (SSS) of normal and abnormal breast and prostate tissues were studied. SS spectra is measured by simultaneously scanning both the excitation and emission wavelengths while keeping a fixed wavelength interval of Δλ = 20 nm. Characteristic, highly resolved peaks and significant spectral differences between normal and different pathological tissues of breast and prostate tissues were observed. The SS spectra of normal and different pathological breast and prostate tissues show the distinct peaks around 300, 350, 450, 500 and 600 nm may be attributed to tryptophan, collagen, NADH, flavin and porphyrin, respectively. Results of the current study demonstrate that the SS spectral changes due to tryptophan, collagen, hemoglobin, NADH, FAD and porphyrin have good diagnostic potential; therefore can be targeted as native tumor markers.
研究了正常和异常乳腺及前列腺组织的斯托克斯位移（SS）光谱（SSS）。SS 光谱通过同时扫描激发和发射波长来测量，同时保持固定的波长间隔Δλ=20nm。在乳腺和前列腺组织的正常和不同病理组织之间观察到特征性的、高分辨率的峰和显著的光谱差异。正常和不同病理乳腺和前列腺组织的 SS 光谱在 300、350、450、500 和 600nm 左右显示出明显的峰，可能分别归因于色氨酸、胶原蛋白、NADH、黄素和卟啉。本研究的结果表明，由于色氨酸、胶原蛋白、血红蛋白、NADH、FAD 和卟啉引起的 SS 光谱变化具有很好的诊断潜力；因此可以作为天然肿瘤标志物的靶标。
