Institut für Pathophysiologie, Universitätsklinikum Essen, Germany.
J Mol Cell Cardiol. 2011 Jun;50(6):951-63. doi: 10.1016/j.yjmcc.2011.02.016. Epub 2011 Mar 5.
The pig heart in situ with regional myocardial ischemia and reperfusion is of unique translational value. Cardiac size, heart rate and blood pressure are similar to those in humans. The temporal and spatial development of myocardial infarction resembles that seen in humans. Technically, the pig heart permits precise control of coronary blood flow during ischemia and reperfusion, includes an intra-individual remote control zone for comparison, and permits the sequential sampling of microdialysates and biopsies for further biochemical, molecular and morphological analyses. Conceptually, all cardioprotective phenomena, including hibernation, ischemic preconditioning, ischemic postconditioning, and remote conditioning, have been demonstrated in pig hearts. The cardioprotective signalling is in part similar, but in part also different from that in rodent hearts.
原位猪心伴有区域性心肌缺血和再灌注具有独特的转化价值。心脏大小、心率和血压与人类相似。心肌梗死的时空发展类似于人类所见。从技术上讲，猪心允许在缺血和再灌注期间精确控制冠状动脉血流，包括用于比较的个体间远程控制区，并允许对微透析液和活检进行顺序取样，以进行进一步的生化、分子和形态学分析。从概念上讲，所有的心脏保护现象，包括冬眠、缺血预处理、缺血后处理和远程预处理，都已经在猪心中得到了证明。心脏保护信号在部分上是相似的，但在部分上也与啮齿动物心脏不同。
