Mann D M, Jones D
Department of Pathology, University of Manchester, U.K.
Neurosci Lett. 1990 Feb 5;109(1-2):68-75. doi: 10.1016/0304-3940(90)90539-l.
Deposition of amyloid (A4) protein was assessed in the cerebral cortex of 26 patients dying with various neurodegenerative disorders, other than Alzheimer's disease. Amyloid deposits were (variably) present in 2/3 (66%) elderly (i.e. over 65 years of age) patients with progressive supranuclear palsy, 4/7 (57%) with Parkinson's disease, 2/5 (40%) with Huntington's chorea and in both elderly patients with frontal lobe dementia but were only rarely seen in any patient before this age. The A4 protein deposits were nearly always of a diffuse type with only an occasional 'cored' neuritic plaque being present. Amyloid deposition in elderly persons may thus relate more to certain aspects of ageing and genetics than to AD, per se. Only in this latter condition are the cerebral cortical amyloid deposits widely associated with a neuritic change and a neurofibrillary degeneration of nerve cells.
对26例死于除阿尔茨海默病以外各种神经退行性疾病的患者大脑皮质进行了淀粉样蛋白（A4）沉积评估。淀粉样蛋白沉积在2/3（66%）患有进行性核上性麻痹的老年（即65岁以上）患者、4/7（57%）帕金森病患者、2/5（40%）亨廷顿舞蹈病患者以及两名老年额叶痴呆患者中（不同程度地）存在，但在该年龄之前的任何患者中很少见到。A4蛋白沉积几乎总是弥漫型，仅偶尔出现“有核”神经炎性斑块。因此，老年人的淀粉样蛋白沉积可能更多地与衰老和遗传学的某些方面有关，而不是与阿尔茨海默病本身有关。只有在后一种情况下，大脑皮质淀粉样蛋白沉积才广泛与神经炎性改变和神经细胞神经原纤维变性相关。
