Armstrong R A
Aston University, Birmingham, UK.
Neurosci Lett. 1994 Aug 29;178(1):59-62. doi: 10.1016/0304-3940(94)90289-5.
beta-amyloid (A beta) deposition in the medial temporal lobe (MTL) was studied in elderly non-demented (ND) cases and in patients with Alzheimer's disease (AD). In AD, A beta deposits were present throughout the MTL although density was less in the hippocampus than the adjacent cortical regions. In the ND cases, no A beta deposits were recorded in 6 cases and in the remaining 8 cases, A beta deposits were confined to the cortical regions adjacent to the hippocampus. The mean density of A beta deposits in the cortical regions examined was greater in AD than in the ND cases but there was a significant overlap between the two groups. The ratio of mature to diffuse A beta deposits was greater in the ND than the AD cases. In both patient groups, A beta deposits formed clusters in the cortex and many tissues exhibited a regular distribution of clusters along the cortex parallel to the pia. The mean dimension of the A beta clusters was greater in AD than in the ND cases. Hence, few aspects of A beta deposition appeared to consistently separate AD from ND cases. However, the spread of A beta pathology between modular units of the cortex and into regions of the hippocampus could be factors in the development of AD.
在老年非痴呆（ND）病例和阿尔茨海默病（AD）患者中，研究了内侧颞叶（MTL）中的β-淀粉样蛋白（Aβ）沉积情况。在AD中，整个MTL均存在Aβ沉积，尽管海马体中的密度低于相邻皮质区域。在ND病例中，6例未记录到Aβ沉积，其余8例中，Aβ沉积局限于海马体相邻的皮质区域。AD中所检查皮质区域的Aβ沉积平均密度高于ND病例，但两组之间存在显著重叠。ND病例中成熟Aβ沉积与弥散性Aβ沉积的比例高于AD病例。在两组患者中，Aβ沉积在皮质中形成簇，许多组织中簇沿着与软脑膜平行的皮质呈规则分布。AD中Aβ簇的平均尺寸大于ND病例。因此，Aβ沉积几乎没有哪方面能始终将AD与ND病例区分开来。然而，Aβ病理在皮质模块化单元之间的扩散以及向海马体区域的扩散可能是AD发病的因素。
