Loeffler D A, LeWitt P A, Juneau P L, Sima A A, Nguyen H U, DeMaggio A J, Brickman C M, Brewer G J, Dick R D, Troyer M D, Kanaley L
Department of Medicine, Sinai Hospital, Detroit, MI 48235, USA.
Brain Res. 1996 Nov 4;738(2):265-74. doi: 10.1016/s0006-8993(96)00782-2.
Ceruloplasmin (CP), the major plasma anti-oxidant and copper transport protein, is synthesized in several tissues, including the brain. We compared regional brain concentrations of CP and copper between subjects with Alzheimer's disease (AD, n = 12), Parkinson's disease (PD, n = 14), Huntington's disease (HD, n = 11), progressive supranuclear palsy (PSP, n = 11), young adult normal controls (YC, n = 6) and elderly normal controls (EC, n = 7). Mean CP concentrations were significantly increased vs. EC (P < 0.05) in AD hippocampus, entorhinal cortex, frontal cortex, and putamen. PD hippocampus, frontal, temporal, and parietal cortices, and HD hippocampus, parietal cortex, and substantia nigra. Immunocytochemical staining for CP in AD hippocampus revealed marked staining within neurons, astrocytes, and neuritic plaques. Increased CP concentrations in brain in these disorders may indicate a localized acute phase-type response and/or a compensatory increase to oxidative stress.
铜蓝蛋白（CP）是主要的血浆抗氧化剂和铜转运蛋白，在包括大脑在内的多种组织中合成。我们比较了患有阿尔茨海默病（AD，n = 12）、帕金森病（PD，n = 14）、亨廷顿病（HD，n = 11）、进行性核上性麻痹（PSP，n = 11）的受试者、年轻成人正常对照组（YC，n = 6）和老年正常对照组（EC，n = 7）之间大脑各区域CP和铜的浓度。与EC相比，AD患者海马体、内嗅皮质、额叶皮质和壳核中的平均CP浓度显著升高（P < 0.05）。PD患者的海马体、额叶、颞叶和顶叶皮质，以及HD患者的海马体、顶叶皮质和黑质中CP浓度也显著升高。AD海马体中CP的免疫细胞化学染色显示神经元、星形胶质细胞和神经炎性斑块内有明显染色。这些疾病中大脑CP浓度升高可能表明存在局部急性期反应和/或对氧化应激的代偿性增加。
