Department of Orthodontics, İnönü University, Maltaya, Turkey.
Eur J Orthod. 2012 Apr;34(2):141-6. doi: 10.1093/ejo/cjq160. Epub 2011 Mar 7.
The aim of this study was to investigate the effects of systemically applied zoledronic acid (ZA) on osteoblastic bone formation and relapse in the rat sagittal suture after expansion. Eighteen 12-week-old male Wistar rats were divided into three groups. In groups 1 and 2, a saline solution was given subcutaneously after expansion and the retention period lasted for 14 and 7 days, respectively. In group 3, 0.1 mg of ZA was diluted with saline and given subcutaneously after expansion: the retention period lasted for 7 days. Computed tomography (CT) measurements were obtained at the start of the study (T1), after expansion (T2), after the retention period (T3), and after the follow-up period (T4). The amount of expansion and relapse and the density of the newly formed bone in the expansion area were measured. The mean bone density values in hounsfield unit (HU) of the newly formed bone were recorded using MX View Workstation. Data were analysed using the Kruskal-Wallis, Friedman, Wilcoxon, and Mann-Whitney U-tests. The results showed that there were significant differences between the groups in the density of newly formed bone after the retention period (P < 0.05). Statistically significant differences were observed when the relapse percentages were compared between the groups (P < 0.05). ZA stimulated bone formation and decreased the relapse ratio after expansion in the rat sagittal suture.
本研究旨在探讨系统性应用唑来膦酸（ZA）对扩张后大鼠矢状缝成骨细胞骨形成和复发的影响。将 18 只 12 周龄雄性 Wistar 大鼠随机分为 3 组。在第 1 组和第 2 组中，在扩张后分别皮下给予生理盐水，保留期持续 14 天和 7 天。在第 3 组中，将 0.1mg ZA 用生理盐水稀释后皮下给予，保留期持续 7 天。在研究开始时（T1）、扩张后（T2）、保留期后（T3）和随访期后（T4）进行 CT 测量。测量扩张量和复发量以及扩张区域新形成骨的密度。使用 MX View 工作站记录新形成骨的平均骨密度值（HU）。使用 Kruskal-Wallis、Friedman、Wilcoxon 和 Mann-Whitney U 检验分析数据。结果显示，保留期后新形成骨的密度在各组之间存在显著差异（P<0.05）。当比较各组之间的复发百分比时，观察到统计学上的显著差异（P<0.05）。ZA 刺激骨形成并减少大鼠矢状缝扩张后的复发率。
